Plasma Fatty Acids in Chronic Kidney Disease: Nervonic Acid Predicts Mortality

Gregory C. Shearer, Juan J. Carrero, Olof Heimbürger, Peter Barany, Peter Stenvinkel

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Although the value of red blood cell fatty acids (FAs) in estimating risk for acute coronary syndrome in the general population is evident, the value of FAs in chronic kidney disease (CKD) is unknown. Here, we provide a pilot analysis in a spectrum of CKD patients. Plasma samples were obtained from 20 incident dialysis patients (CKD stage 5), matched with samples from 10 CKD stage 3-4 patients, and 10 control subjects. Whole plasma FAs were measured using gas chromatography. Whereas neither linoleic acid nor arachidonate acid were altered in CKD, metabolic intermediates of arachidonate synthesis (γ-linolenate and dihomo γ-linolenate) were reduced in CKD. Demming (orthogonal) correlation of FA abundance with estimated GFR identified several saturated and unsaturated FAs in addition to the intermediates; again, neither linoleate nor arachidonate were related. Follow-up data within the CKD stage 5 patients revealed that nervonic acid, a component of membrane sphingolipids and phosphatidylethanolamines, was a significant predictor of all-cause mortality; the age-adjusted relative risk for a 0.15% change is 2.1 (1.4, 3.7; 95% CI; P = .0008). These findings support the exploration of FAs in larger studies for validation of the role FAs in cardiovascular risk and mortality in CKD.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalJournal of Renal Nutrition
Volume22
Issue number2
DOIs
StatePublished - Mar 1 2012

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Chronic Renal Insufficiency
Fatty Acids
Mortality
alpha-Linolenic Acid
Linoleic Acid
Phosphatidylethanolamines
Sphingolipids
nervonic acid
Validation Studies
Acute Coronary Syndrome
Unsaturated Fatty Acids
Gas Chromatography
Dialysis
Erythrocytes
Acids
Membranes
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Nephrology

Cite this

Shearer, Gregory C. ; Carrero, Juan J. ; Heimbürger, Olof ; Barany, Peter ; Stenvinkel, Peter. / Plasma Fatty Acids in Chronic Kidney Disease : Nervonic Acid Predicts Mortality. In: Journal of Renal Nutrition. 2012 ; Vol. 22, No. 2. pp. 277-283.
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Plasma Fatty Acids in Chronic Kidney Disease : Nervonic Acid Predicts Mortality. / Shearer, Gregory C.; Carrero, Juan J.; Heimbürger, Olof; Barany, Peter; Stenvinkel, Peter.

In: Journal of Renal Nutrition, Vol. 22, No. 2, 01.03.2012, p. 277-283.

Research output: Contribution to journalArticle

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