Plasma prostaglandins in hypercalcemic patients with neoplastic disease

Laurence Demers, J. C. Allegra, Harold Harvey, Allan Lipton, J. R. Luderer, R. Mortel, D. E. Brenner

Research output: Contribution to journalArticlepeer-review

59 Scopus citations

Abstract

Peripheral plasma prostaglandin E (PGE) determinations were performed on a series of 79 patients with solid tumor neoplasms and correlated with their serum calcium levels. Fourteen patients were hypercalcemic and 11 of these had significant elevations in circulating plasma PGE. Ten of the hypercalcemic group had extensive metastases to bone. These findings support the recently developed hypothesis that prostaglandins are causally related to the genesis of hypercalcemia in malignancy.

Original languageEnglish (US)
Pages (from-to)1559-1562
Number of pages4
JournalCancer
Volume39
Issue number4
DOIs
StatePublished - Apr 1977

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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