Plasmodium falciparum infection increases Anopheles gambiae attraction to nectar sources and sugar uptake

Vincent O. Nyasembe, Peter E.A. Teal, Patrick Sawa, James H. Tumlinson, Christian Borgemeister, Baldwyn Torto

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Plasmodium parasites are known to manipulate the behavior of their vectors so as to enhance transmission [1-4]. From an evolutionary standpoint, behavior manipulation by the parasite should expose the vector to limited risk of early mortality while ensuring sufficient energy supply for both it and the vector [5, 6]. However, it is unknown whether this vector manipulation also affects vector-plant interaction and sugar uptake. Here, we show that the attraction of Anopheles gambiae s.s. to plant odors increased by 30% and 24% after infection with the oocyst and sporozoite stages of Plasmodium falciparum, respectively, while probing activity increased by 77% and 80%, respectively, when the vectors were infected with the two stages of the parasite. Our data also reveal an increased sugar uptake at the oocyst stage that decreased at the sporozoite stage of infection compared to uninfected An. gambiae, with depletion of lipid reserves at the sporozoite stage. These results point to a possible physiological adjustment by An. gambiae to P. falciparum infection or behavior manipulation of An. gambiae by P. falciparum to enhance transmission. We conclude that the nectar-seeking behavior of P. falciparum-infected An. gambiae appears to be modified in a manner governed by the vector's fight for survival and the parasite's need to advance its transmission.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalCurrent Biology
Volume24
Issue number2
DOIs
StatePublished - Jan 20 2014

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Plant Nectar
Anopheles gambiae
Plasmodium falciparum
nectar
Sugars
Malaria
Sporozoites
sporozoites
sugars
uptake mechanisms
Parasites
parasites
infection
Oocysts
oocysts
Social Adjustment
Plasmodium
Infection
Odors
odors

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Nyasembe, Vincent O. ; Teal, Peter E.A. ; Sawa, Patrick ; Tumlinson, James H. ; Borgemeister, Christian ; Torto, Baldwyn. / Plasmodium falciparum infection increases Anopheles gambiae attraction to nectar sources and sugar uptake. In: Current Biology. 2014 ; Vol. 24, No. 2. pp. 217-221.
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Plasmodium falciparum infection increases Anopheles gambiae attraction to nectar sources and sugar uptake. / Nyasembe, Vincent O.; Teal, Peter E.A.; Sawa, Patrick; Tumlinson, James H.; Borgemeister, Christian; Torto, Baldwyn.

In: Current Biology, Vol. 24, No. 2, 20.01.2014, p. 217-221.

Research output: Contribution to journalArticle

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