Plasmodium gene regulation: far more to factor in

Manuel Llinás, Kirk W. Deitsch, Till S. Voss

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations

Abstract

Gene expression in the malaria parasite has received generous attention over the past several decades, predominantly because of the importance of var gene regulation, which is key to antigenic variation and host immune evasion. However, the role of transcriptional regulation in governing other genes expressed during the various stages of development has remained less well characterized. This mostly has been due to the lack of defined transcriptional regulators in Plasmodium parasites. Here, we describe recent advances that have become possible by joining traditional biochemistry with new technological innovations. These studies have increased our understanding of the role of transcriptional regulation, not only in the control of gene expression for antigenic variation but also in the coordination of stage-specific parasite development.

Original languageEnglish (US)
Pages (from-to)551-556
Number of pages6
JournalTrends in Parasitology
Volume24
Issue number12
DOIs
StatePublished - Dec 2008

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

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