Plasmodium vivax parasites alter the balance of myeloid and plasmacytoid dendritic cells and the induction of regulatory T cells

Kulachart Jangpatarapongsa, Patchanee Chootong, Jetsumon Sattabongkot, Kesinee Chotivanich, Jeeraphat Sirichaisinthop, Sumalee Tungpradabkul, Hajime Hisaeda, Marita Troye-Blomberg, Liwang Cui, Rachanee Udomsangpetch

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

Immunity induced by Plasmodium vivax infections leads to memory T-cell recruitment and activation during subsequent infections. Here, we investigated the role of regulatory T cells (Treg) in coordination with the host immune response during P. vivax infection. Our results showed a significant increase in the percentage of FOXP3+ Treg, IL-10-secreting Type I Treg (Tr1) and IL-10 levels in patients with acute P. vivax infection as compared with those found in either naïve or immune controls. The concurrent increase in the Treg population could also be reproduced in vitro using peripheral blood mononuclear cells from naïve controls stimulated with crude antigens extracted from P. vivax-infected red blood cells. Acute P. vivax infections were associated with a significant decrease in the numbers of DC, indicating a general immunosuppression during P. vivax infections. However, unlike P. falciparum infections, we found that the ratio of myeloid DC (MDC) to plasmacytoid DC (PDC) was significantly lower in acute P. vivax patients than that of naïve and immune controls. Moreover, the reduction in PDC may be partly responsible for the poor antibody responses during P. vivax infections. Taken together, these results suggest that P. vivax parasites interact with DC, which alters the MDC/PDC ratio that potentially leads to Treg activation and IL-10 release.

Original languageEnglish (US)
Pages (from-to)2697-2705
Number of pages9
JournalEuropean Journal of Immunology
Volume38
Issue number10
DOIs
StatePublished - 2008

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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