Platelet activating factor and its metabolite promote sleep in rabbits

Tetsuya Kushikata, Jidong Fang, James M. Krueger

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Platelet activating factor (PAF) is a key inflammatory mediator. PAF and its receptor are found in brain and PAF affects or is affected by the production of sleep promoting cytokines such as interleukin-1. PAF also interacts with several other sleep-regulatory substances such as nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, nitric oxide, prostaglandins, and prolactin. We thus hypothesized that PAF would increase sleep. In these experiments, each rabbit received an injection of 25 μl of 2% DMSO to obtain control values, and on a separate day received PAF or lyso-PAF, a metabolite of PAF. Ten, 100 and 500 nmol for each substance was injected intracerebroventricularly. Both PAF and lyso-PAF enhanced non-rapid eye movement (NREM) sleep but not REM sleep. Lyso-PAF, but not PAF, induced hyperthermia. Results are consistent with the hypothesis that the brain cytokine network is involved in physiological sleep regulation.

Original languageEnglish (US)
Pages (from-to)233-238
Number of pages6
JournalNeuroscience Letters
Volume394
Issue number3
DOIs
StatePublished - Feb 20 2006

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Platelet Activating Factor
Sleep
Rabbits
Cytokines
Neurotrophin 3
Induced Hyperthermia
Brain-Derived Neurotrophic Factor
REM Sleep
Brain
Nerve Growth Factor
Eye Movements
Dimethyl Sulfoxide
Interleukin-1
Prolactin
Prostaglandins
Nitric Oxide
Injections

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kushikata, Tetsuya ; Fang, Jidong ; Krueger, James M. / Platelet activating factor and its metabolite promote sleep in rabbits. In: Neuroscience Letters. 2006 ; Vol. 394, No. 3. pp. 233-238.
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Platelet activating factor and its metabolite promote sleep in rabbits. / Kushikata, Tetsuya; Fang, Jidong; Krueger, James M.

In: Neuroscience Letters, Vol. 394, No. 3, 20.02.2006, p. 233-238.

Research output: Contribution to journalArticle

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