Platelet function analysis in children with Schönlein-Henoch syndrome

Srdana Culic, Rudolf Jakl, Vitomir Metlicic, Branka Paukovic-Sekulic, Biserka Resic, Vida Culic, Dubravka Kuljis, Dragan Primorac

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background. Schönlein-Henoch syndrome (SHS) or anaphylactic purpura in childhood is the result of pathologic and immunologic responses to different antigens. These antigens could induce the formation of immune complexes responsible for vasculitis and their precipitation on the endothelium of small blood vessels. Purpuric bruises, hematuria, hematemesis, melena, or hematohesis may suggest coagulation disturbances. Increasing bleeding tendency may suggest platelet function disturbance. To examine the qualitative function of platelets in children with SHS, we decided to analyze its aggregation function. Methods. Using the Born method of testing, we analyzed platelet aggregation in 24 children with SHS. Results. Based on the aggregograms examined, we observed that most patients had abnormal aggregation curves, in which platelets demonstrated a block of release of the endogenous ADP, with or without desaggregation. Conclusions. One clinical symptom of SHS appearing in most patients is a mild or increased tendency toward bleeding. On measuring induced aggregation of platelets in children with SHS, we observed that the qualitative function of platelets was disturbed.

Original languageEnglish (US)
Pages (from-to)268-272
Number of pages5
JournalArchives of Medical Research
Volume32
Issue number4
DOIs
StatePublished - Jan 1 2001

Fingerprint

Blood Platelets
Platelet Aggregation
Hemorrhage
Melena
Hematemesis
Antigens
Purpura
Contusions
Hematuria
Vasculitis
Antigen-Antibody Complex
Adenosine Diphosphate
Endothelium
Blood Vessels

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Culic, S., Jakl, R., Metlicic, V., Paukovic-Sekulic, B., Resic, B., Culic, V., ... Primorac, D. (2001). Platelet function analysis in children with Schönlein-Henoch syndrome. Archives of Medical Research, 32(4), 268-272. https://doi.org/10.1016/S0188-4409(01)00282-X
Culic, Srdana ; Jakl, Rudolf ; Metlicic, Vitomir ; Paukovic-Sekulic, Branka ; Resic, Biserka ; Culic, Vida ; Kuljis, Dubravka ; Primorac, Dragan. / Platelet function analysis in children with Schönlein-Henoch syndrome. In: Archives of Medical Research. 2001 ; Vol. 32, No. 4. pp. 268-272.
@article{626aea30033c48f6856f6402fca05daa,
title = "Platelet function analysis in children with Sch{\"o}nlein-Henoch syndrome",
abstract = "Background. Sch{\"o}nlein-Henoch syndrome (SHS) or anaphylactic purpura in childhood is the result of pathologic and immunologic responses to different antigens. These antigens could induce the formation of immune complexes responsible for vasculitis and their precipitation on the endothelium of small blood vessels. Purpuric bruises, hematuria, hematemesis, melena, or hematohesis may suggest coagulation disturbances. Increasing bleeding tendency may suggest platelet function disturbance. To examine the qualitative function of platelets in children with SHS, we decided to analyze its aggregation function. Methods. Using the Born method of testing, we analyzed platelet aggregation in 24 children with SHS. Results. Based on the aggregograms examined, we observed that most patients had abnormal aggregation curves, in which platelets demonstrated a block of release of the endogenous ADP, with or without desaggregation. Conclusions. One clinical symptom of SHS appearing in most patients is a mild or increased tendency toward bleeding. On measuring induced aggregation of platelets in children with SHS, we observed that the qualitative function of platelets was disturbed.",
author = "Srdana Culic and Rudolf Jakl and Vitomir Metlicic and Branka Paukovic-Sekulic and Biserka Resic and Vida Culic and Dubravka Kuljis and Dragan Primorac",
year = "2001",
month = "1",
day = "1",
doi = "10.1016/S0188-4409(01)00282-X",
language = "English (US)",
volume = "32",
pages = "268--272",
journal = "Archives of Medical Research",
issn = "0188-4409",
publisher = "Elsevier Inc.",
number = "4",

}

Culic, S, Jakl, R, Metlicic, V, Paukovic-Sekulic, B, Resic, B, Culic, V, Kuljis, D & Primorac, D 2001, 'Platelet function analysis in children with Schönlein-Henoch syndrome', Archives of Medical Research, vol. 32, no. 4, pp. 268-272. https://doi.org/10.1016/S0188-4409(01)00282-X

Platelet function analysis in children with Schönlein-Henoch syndrome. / Culic, Srdana; Jakl, Rudolf; Metlicic, Vitomir; Paukovic-Sekulic, Branka; Resic, Biserka; Culic, Vida; Kuljis, Dubravka; Primorac, Dragan.

In: Archives of Medical Research, Vol. 32, No. 4, 01.01.2001, p. 268-272.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Platelet function analysis in children with Schönlein-Henoch syndrome

AU - Culic, Srdana

AU - Jakl, Rudolf

AU - Metlicic, Vitomir

AU - Paukovic-Sekulic, Branka

AU - Resic, Biserka

AU - Culic, Vida

AU - Kuljis, Dubravka

AU - Primorac, Dragan

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Background. Schönlein-Henoch syndrome (SHS) or anaphylactic purpura in childhood is the result of pathologic and immunologic responses to different antigens. These antigens could induce the formation of immune complexes responsible for vasculitis and their precipitation on the endothelium of small blood vessels. Purpuric bruises, hematuria, hematemesis, melena, or hematohesis may suggest coagulation disturbances. Increasing bleeding tendency may suggest platelet function disturbance. To examine the qualitative function of platelets in children with SHS, we decided to analyze its aggregation function. Methods. Using the Born method of testing, we analyzed platelet aggregation in 24 children with SHS. Results. Based on the aggregograms examined, we observed that most patients had abnormal aggregation curves, in which platelets demonstrated a block of release of the endogenous ADP, with or without desaggregation. Conclusions. One clinical symptom of SHS appearing in most patients is a mild or increased tendency toward bleeding. On measuring induced aggregation of platelets in children with SHS, we observed that the qualitative function of platelets was disturbed.

AB - Background. Schönlein-Henoch syndrome (SHS) or anaphylactic purpura in childhood is the result of pathologic and immunologic responses to different antigens. These antigens could induce the formation of immune complexes responsible for vasculitis and their precipitation on the endothelium of small blood vessels. Purpuric bruises, hematuria, hematemesis, melena, or hematohesis may suggest coagulation disturbances. Increasing bleeding tendency may suggest platelet function disturbance. To examine the qualitative function of platelets in children with SHS, we decided to analyze its aggregation function. Methods. Using the Born method of testing, we analyzed platelet aggregation in 24 children with SHS. Results. Based on the aggregograms examined, we observed that most patients had abnormal aggregation curves, in which platelets demonstrated a block of release of the endogenous ADP, with or without desaggregation. Conclusions. One clinical symptom of SHS appearing in most patients is a mild or increased tendency toward bleeding. On measuring induced aggregation of platelets in children with SHS, we observed that the qualitative function of platelets was disturbed.

UR - http://www.scopus.com/inward/record.url?scp=0034953610&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034953610&partnerID=8YFLogxK

U2 - 10.1016/S0188-4409(01)00282-X

DO - 10.1016/S0188-4409(01)00282-X

M3 - Article

C2 - 11440781

AN - SCOPUS:0034953610

VL - 32

SP - 268

EP - 272

JO - Archives of Medical Research

JF - Archives of Medical Research

SN - 0188-4409

IS - 4

ER -

Culic S, Jakl R, Metlicic V, Paukovic-Sekulic B, Resic B, Culic V et al. Platelet function analysis in children with Schönlein-Henoch syndrome. Archives of Medical Research. 2001 Jan 1;32(4):268-272. https://doi.org/10.1016/S0188-4409(01)00282-X