Abstract
The May-Hegglin anomaly is one of the rare forms of hereditary thrombocytopenia. Since fewer than 100 cases of May-Hegglin anomaly have been described to date, major controversies regarding the adequacy of hemostasis in vivo and abnormalities of platelet function in vitro continue to prevail. This report describes the results of coagulation, platelet function, platelet ultrastructure, and survival studies performed for a family with 6 previously unreported cases occurring in 3 generations. One member of this family also had frequent epistaxis and a prolonged bleeding time associated with cyanotic heart disease that required open heart surgery for correction. The laboratory assessment of hemostasis in such patients before major surgery is also discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 663-668 |
| Number of pages | 6 |
| Journal | Unknown Journal |
| Volume | 74 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1980 |
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All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
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Platelet function, ultrastructure, and survival in the May-Hegglin anomaly. / Hamilton, Robert; Shaikh, B. S.; Ottie, J. N.; Storch, A. E.; Saleem, A.; White, J. G.
In: Unknown Journal, Vol. 74, No. 5, 01.01.1980, p. 663-668.Research output: Contribution to journal › Article
TY - JOUR
T1 - Platelet function, ultrastructure, and survival in the May-Hegglin anomaly
AU - Hamilton, Robert
AU - Shaikh, B. S.
AU - Ottie, J. N.
AU - Storch, A. E.
AU - Saleem, A.
AU - White, J. G.
PY - 1980/1/1
Y1 - 1980/1/1
N2 - The May-Hegglin anomaly is one of the rare forms of hereditary thrombocytopenia. Since fewer than 100 cases of May-Hegglin anomaly have been described to date, major controversies regarding the adequacy of hemostasis in vivo and abnormalities of platelet function in vitro continue to prevail. This report describes the results of coagulation, platelet function, platelet ultrastructure, and survival studies performed for a family with 6 previously unreported cases occurring in 3 generations. One member of this family also had frequent epistaxis and a prolonged bleeding time associated with cyanotic heart disease that required open heart surgery for correction. The laboratory assessment of hemostasis in such patients before major surgery is also discussed.
AB - The May-Hegglin anomaly is one of the rare forms of hereditary thrombocytopenia. Since fewer than 100 cases of May-Hegglin anomaly have been described to date, major controversies regarding the adequacy of hemostasis in vivo and abnormalities of platelet function in vitro continue to prevail. This report describes the results of coagulation, platelet function, platelet ultrastructure, and survival studies performed for a family with 6 previously unreported cases occurring in 3 generations. One member of this family also had frequent epistaxis and a prolonged bleeding time associated with cyanotic heart disease that required open heart surgery for correction. The laboratory assessment of hemostasis in such patients before major surgery is also discussed.
UR - http://www.scopus.com/inward/record.url?scp=0019127648&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019127648&partnerID=8YFLogxK
U2 - 10.1093/ajcp/74.5.663
DO - 10.1093/ajcp/74.5.663
M3 - Article
C2 - 7446470
AN - SCOPUS:0019127648
VL - 74
SP - 663
EP - 668
JO - [No source information available]
JF - [No source information available]
SN - 0042-1215
IS - 5
ER -