POLARIZATION AND ADSORPTION EFFECTS ON SIEVING IN MEMBRANE PROTEIN FILTRATION.

Bruce C. Robertson, Andrew Zydney

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The authors have developed a theoretic model to predict both the measured sieving coefficient and the ultrafiltrate flux in an unstirred batch filtration cell. Model predictions are in good agreement with experimental data, providing quantitative evidence for the effects of protein polarization on flux and sieving. In addition, results indicate that protein adsorption plays an important role in membrane filtration. The model for the unstirred cell permits very accurate evaluation of intrinsic membrane sieving coefficients for highly rejected proteins. These results are critical in the design and analysis of selective protein filtration devices, e. g. , cascade filtration for separation of albumin from immunoglobulins.

Original languageEnglish (US)
Pages (from-to)118-122
Number of pages5
JournalASAIO Transactions
Volume33
Issue number3
StatePublished - Jul 1987

All Science Journal Classification (ASJC) codes

  • Biophysics

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