Polyamines and neoplastic growth

Anthony Pegg, D. J. Feith

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Studies over many years have suggested that increased polyamine synthesis may be necessary for neoplastic growth. This review summarizes recent work on the regulation of putrescine production both de novo and via the degradation of higher polyamines and provides a summary of studies using transgenic mice in which the levels of proteins that regulate these processes (L-ornithine decarboxylase, antizyme and spermidine/spermine-N1-acetyltransferase) are altered.

Original languageEnglish (US)
Pages (from-to)295-299
Number of pages5
JournalBiochemical Society Transactions
Volume35
Issue number2
DOIs
StatePublished - Apr 1 2007

Fingerprint

Polyamines
Acetyltransferases
Putrescine
Spermidine
Spermine
Growth
Transgenic Mice
Degradation
Proteins
ornithine decarboxylase antizyme
diamine N-acetyltransferase

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Pegg, Anthony ; Feith, D. J. / Polyamines and neoplastic growth. In: Biochemical Society Transactions. 2007 ; Vol. 35, No. 2. pp. 295-299.
@article{422bb7ffbde04a08b94b9ca6e892cc52,
title = "Polyamines and neoplastic growth",
abstract = "Studies over many years have suggested that increased polyamine synthesis may be necessary for neoplastic growth. This review summarizes recent work on the regulation of putrescine production both de novo and via the degradation of higher polyamines and provides a summary of studies using transgenic mice in which the levels of proteins that regulate these processes (L-ornithine decarboxylase, antizyme and spermidine/spermine-N1-acetyltransferase) are altered.",
author = "Anthony Pegg and Feith, {D. J.}",
year = "2007",
month = "4",
day = "1",
doi = "10.1042/BST0350295",
language = "English (US)",
volume = "35",
pages = "295--299",
journal = "Biochemical Society Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd.",
number = "2",

}

Polyamines and neoplastic growth. / Pegg, Anthony; Feith, D. J.

In: Biochemical Society Transactions, Vol. 35, No. 2, 01.04.2007, p. 295-299.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polyamines and neoplastic growth

AU - Pegg, Anthony

AU - Feith, D. J.

PY - 2007/4/1

Y1 - 2007/4/1

N2 - Studies over many years have suggested that increased polyamine synthesis may be necessary for neoplastic growth. This review summarizes recent work on the regulation of putrescine production both de novo and via the degradation of higher polyamines and provides a summary of studies using transgenic mice in which the levels of proteins that regulate these processes (L-ornithine decarboxylase, antizyme and spermidine/spermine-N1-acetyltransferase) are altered.

AB - Studies over many years have suggested that increased polyamine synthesis may be necessary for neoplastic growth. This review summarizes recent work on the regulation of putrescine production both de novo and via the degradation of higher polyamines and provides a summary of studies using transgenic mice in which the levels of proteins that regulate these processes (L-ornithine decarboxylase, antizyme and spermidine/spermine-N1-acetyltransferase) are altered.

UR - http://www.scopus.com/inward/record.url?scp=34247099261&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247099261&partnerID=8YFLogxK

U2 - 10.1042/BST0350295

DO - 10.1042/BST0350295

M3 - Article

C2 - 17371264

AN - SCOPUS:34247099261

VL - 35

SP - 295

EP - 299

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

SN - 0300-5127

IS - 2

ER -