Polyclonal hematopoiesis in interferon-induced cytogenetic remissions of chronic myelogenous leukemia

David Claxton, A. Deisseroth, M. Talpaz, C. Reading, H. Kantarjian, J. Trujillo, S. Stass, G. Gooch, G. Spitzer

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Interferon (IFN) therapy of early chronic myelogenous leukemia (CML) frequently produces partial or complete cytogenetic remission of the disease. Patients with complete cytogenetic remission often continue on therapy for several years with bone marrow showing only diploid (normal) metaphases. We studied hematopoiesis in five female patients with major cytogenetic remissions from CML during IFN therapy. Clonality analysis using the BstXI PGK gene polymorphism showed that granulocytes were nonclonal in all patients during cytogenetic remission. BCR region studies showed rearrangement only in the one patient whose remission was incomplete at the time of sampling. Granulopoiesis is nonclonal in IFN-induced remissions of CML and may be derived from normal hematopoietic stem cells.

Original languageEnglish (US)
Pages (from-to)997-1002
Number of pages6
JournalBlood
Volume79
Issue number4
StatePublished - Jan 1 1992

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Hematopoiesis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cytogenetics
Interferons
Stem cells
Polymorphism
Bone
Metaphase
Hematopoietic Stem Cells
Genes
Diploidy
Granulocytes
Sampling
Therapeutics
Bone Marrow

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Claxton, D., Deisseroth, A., Talpaz, M., Reading, C., Kantarjian, H., Trujillo, J., ... Spitzer, G. (1992). Polyclonal hematopoiesis in interferon-induced cytogenetic remissions of chronic myelogenous leukemia. Blood, 79(4), 997-1002.
Claxton, David ; Deisseroth, A. ; Talpaz, M. ; Reading, C. ; Kantarjian, H. ; Trujillo, J. ; Stass, S. ; Gooch, G. ; Spitzer, G. / Polyclonal hematopoiesis in interferon-induced cytogenetic remissions of chronic myelogenous leukemia. In: Blood. 1992 ; Vol. 79, No. 4. pp. 997-1002.
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Claxton, D, Deisseroth, A, Talpaz, M, Reading, C, Kantarjian, H, Trujillo, J, Stass, S, Gooch, G & Spitzer, G 1992, 'Polyclonal hematopoiesis in interferon-induced cytogenetic remissions of chronic myelogenous leukemia', Blood, vol. 79, no. 4, pp. 997-1002.

Polyclonal hematopoiesis in interferon-induced cytogenetic remissions of chronic myelogenous leukemia. / Claxton, David; Deisseroth, A.; Talpaz, M.; Reading, C.; Kantarjian, H.; Trujillo, J.; Stass, S.; Gooch, G.; Spitzer, G.

In: Blood, Vol. 79, No. 4, 01.01.1992, p. 997-1002.

Research output: Contribution to journalArticle

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AU - Claxton, David

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Claxton D, Deisseroth A, Talpaz M, Reading C, Kantarjian H, Trujillo J et al. Polyclonal hematopoiesis in interferon-induced cytogenetic remissions of chronic myelogenous leukemia. Blood. 1992 Jan 1;79(4):997-1002.