Polyclonal hematopoiesis in interferon-induced cytogenetic remissions of chronic myelogenous leukemia

D. Claxton, A. Deisseroth, M. Talpaz, C. Reading, H. Kantarjian, J. Trujillo, S. Stass, G. Gooch, G. Spitzer

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Interferon (IFN) therapy of early chronic myelogenous leukemia (CML) frequently produces partial or complete cytogenetic remission of the disease. Patients with complete cytogenetic remission often continue on therapy for several years with bone marrow showing only diploid (normal) metaphases. We studied hematopoiesis in five female patients with major cytogenetic remissions from CML during IFN therapy. Clonality analysis using the BstXI PGK gene polymorphism showed that granulocytes were nonclonal in all patients during cytogenetic remission. BCR region studies showed rearrangement only in the one patient whose remission was incomplete at the time of sampling. Granulopoiesis is nonclonal in IFN-induced remissions of CML and may be derived from normal hematopoietic stem cells.

Original languageEnglish (US)
Pages (from-to)997-1002
Number of pages6
JournalBlood
Volume79
Issue number4
DOIs
StatePublished - 1992

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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