9 Citations (Scopus)

Abstract

Our understanding of Polycystic Ovary Syndrome (PCOS) has been hampered by varying diagnostic criteria, and ignorance of the etiology of the syndrome. PCOS women are uniquely insulin resistant and obesity aggravates this underlying predisposition to insulin resistance. Diagnostic criteria which focus on hyperandrogenism and/or menstrual irregularity are more likely to identify insulin resistant women, than such criteria as abnormal gonadotropin secretion or ovarian morphology. The lack of a clear etiologic mechanism to the syndrome has led to a multitude of symptom-oriented treatments with few therapies improving all aspects of the endocrine syndrome of PCOS. Improving insulin sensitivity has become established as a baseline treatment strategy in PCOS. There are, however, few randomized controlled trials of adequate power to provide an evidence based guide to treatment in PCOS.

Original languageEnglish (US)
Pages (from-to)219-225
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume186
Issue number2
DOIs
StatePublished - Jan 25 2002

Fingerprint

Polycystic Ovary Syndrome
Insulin
Insulin Resistance
Hyperandrogenism
Gonadotropins
Therapeutics
Randomized Controlled Trials
Obesity

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Endocrinology

Cite this

@article{3bccca68f6a24084a398c17a733ff059,
title = "Polycystic ovary syndrome: The new millenium",
abstract = "Our understanding of Polycystic Ovary Syndrome (PCOS) has been hampered by varying diagnostic criteria, and ignorance of the etiology of the syndrome. PCOS women are uniquely insulin resistant and obesity aggravates this underlying predisposition to insulin resistance. Diagnostic criteria which focus on hyperandrogenism and/or menstrual irregularity are more likely to identify insulin resistant women, than such criteria as abnormal gonadotropin secretion or ovarian morphology. The lack of a clear etiologic mechanism to the syndrome has led to a multitude of symptom-oriented treatments with few therapies improving all aspects of the endocrine syndrome of PCOS. Improving insulin sensitivity has become established as a baseline treatment strategy in PCOS. There are, however, few randomized controlled trials of adequate power to provide an evidence based guide to treatment in PCOS.",
author = "Legro, {Richard S.}",
year = "2002",
month = "1",
day = "25",
doi = "10.1016/S0303-7207(02)00033-3",
language = "English (US)",
volume = "186",
pages = "219--225",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

Polycystic ovary syndrome : The new millenium. / Legro, Richard S.

In: Molecular and Cellular Endocrinology, Vol. 186, No. 2, 25.01.2002, p. 219-225.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Polycystic ovary syndrome

T2 - The new millenium

AU - Legro, Richard S.

PY - 2002/1/25

Y1 - 2002/1/25

N2 - Our understanding of Polycystic Ovary Syndrome (PCOS) has been hampered by varying diagnostic criteria, and ignorance of the etiology of the syndrome. PCOS women are uniquely insulin resistant and obesity aggravates this underlying predisposition to insulin resistance. Diagnostic criteria which focus on hyperandrogenism and/or menstrual irregularity are more likely to identify insulin resistant women, than such criteria as abnormal gonadotropin secretion or ovarian morphology. The lack of a clear etiologic mechanism to the syndrome has led to a multitude of symptom-oriented treatments with few therapies improving all aspects of the endocrine syndrome of PCOS. Improving insulin sensitivity has become established as a baseline treatment strategy in PCOS. There are, however, few randomized controlled trials of adequate power to provide an evidence based guide to treatment in PCOS.

AB - Our understanding of Polycystic Ovary Syndrome (PCOS) has been hampered by varying diagnostic criteria, and ignorance of the etiology of the syndrome. PCOS women are uniquely insulin resistant and obesity aggravates this underlying predisposition to insulin resistance. Diagnostic criteria which focus on hyperandrogenism and/or menstrual irregularity are more likely to identify insulin resistant women, than such criteria as abnormal gonadotropin secretion or ovarian morphology. The lack of a clear etiologic mechanism to the syndrome has led to a multitude of symptom-oriented treatments with few therapies improving all aspects of the endocrine syndrome of PCOS. Improving insulin sensitivity has become established as a baseline treatment strategy in PCOS. There are, however, few randomized controlled trials of adequate power to provide an evidence based guide to treatment in PCOS.

UR - http://www.scopus.com/inward/record.url?scp=0037168911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037168911&partnerID=8YFLogxK

U2 - 10.1016/S0303-7207(02)00033-3

DO - 10.1016/S0303-7207(02)00033-3

M3 - Article

AN - SCOPUS:0037168911

VL - 186

SP - 219

EP - 225

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

IS - 2

ER -