Polymeric micelle-based hydrogen sulfide donors

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Hydrogen sulfide (H2S) serves as a gaseous signal-transmitter molecule in the human body that regulates inflammation, relaxes vascular smooth muscles, promotes angiogenesis and mediates neurotransmission. With the discovery of the biological significance of H2S, the potential for H2S-based therapies has attracted growing attention. However, due to its volatile nature and a short half-life under physiological conditions, development of H2S delivery systems, which enables the release of H2S at the site of interest in a controlled manner are needed in order to explore its full therapeutic potential. One common approach is to use H2S donor compounds, such as anethole dithiolethione (ADT) derivatives, which generate H2S under physiological conditions. However, the fast and uncontrolled rate of H2S release, toxic side effects of the donor compounds and/or their decomposition byproducts as well as rapid renal clearance remain as the major problems associated with the use of small H2S donor compounds. To address this issue, we developed nano-sized gas donors based on polymeric micelles (H2S donor micelles, Figure 1) which enable sustained H2S release under physiological conditions. Here, we report design, synthesis and characterization of polymeric H2S donor micelles containing anethole dithiolethione (ADT) moieties. Furthermore, the anti-cancer activities of these micelles were evaluated in the in vitro cell culture assays as well as the in ovo chick chorioallantoic membrane (CAM) assay.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages748
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period4/3/194/6/19

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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