Poly(DL-lactide)s (PDLLA) were prepared by ring opening polymerization, and then transesterified with polyethylene glycol (PEG). Polymeric particles with different sizes were produced by solvent evaporation, by stirring, and by sonication. The average size and size distribution were determined by SEM. A model drug, rifampicin, was loaded within these particles. Release from these matrices was studied in vitro. Higher rifampicin release rates were obtained from low molecular weight PDLLA-prepared particles which degraded faster.
|Original language||English (US)|
|Journal||Artificial Cells, Blood Substitutes, and Immobilization Biotechnology|
|Publication status||Published - Nov 1994|
All Science Journal Classification (ASJC) codes
- Biomedical Engineering