Polymeric microcarriers from PDLLA homopolymers and PDLLA/PEG copolymers as drug carriers

E. Denkbas, X. Kaitian, A. Kozluca, E. Piskin

Research output: Contribution to journalArticle

Abstract

Poly(DL-lactide)s (PDLLA) were prepared by ring opening polymerization, and then transesterified with polyethylene glycol (PEG). Polymeric particles with different sizes were produced by solvent evaporation, by stirring, and by sonication. The average size and size distribution were determined by SEM. A model drug, rifampicin, was loaded within these particles. Release from these matrices was studied in vitro. Higher rifampicin release rates were obtained from low molecular weight PDLLA-prepared particles which degraded faster.

Original languageEnglish (US)
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
StatePublished - Nov 1994

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Drug Carriers
Sonication
Ring opening polymerization
Rifampin
Homopolymerization
Polyethylene glycols
Evaporation
Copolymers
Molecular weight
Scanning electron microscopy
Polymerization
Molecular Weight
Pharmaceutical Preparations
poly(lactide)
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomedical Engineering

Cite this

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Polymeric microcarriers from PDLLA homopolymers and PDLLA/PEG copolymers as drug carriers. / Denkbas, E.; Kaitian, X.; Kozluca, A.; Piskin, E.

In: Artificial Cells, Blood Substitutes, and Immobilization Biotechnology, Vol. 22, No. 5, 11.1994.

Research output: Contribution to journalArticle

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T1 - Polymeric microcarriers from PDLLA homopolymers and PDLLA/PEG copolymers as drug carriers

AU - Denkbas, E.

AU - Kaitian, X.

AU - Kozluca, A.

AU - Piskin, E.

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