Polymeric microcarriers from PDLLA homopolymers and PDLLA/PEG copolymers as drug carriers

E. Denkbas, X. Kaitian, A. Kozluca, E. Piskin

Research output: Contribution to journalArticle

Abstract

Poly(DL-lactide)s (PDLLA) were prepared by ring opening polymerization, and then transesterified with polyethylene glycol (PEG). Polymeric particles with different sizes were produced by solvent evaporation, by stirring, and by sonication. The average size and size distribution were determined by SEM. A model drug, rifampicin, was loaded within these particles. Release from these matrices was studied in vitro. Higher rifampicin release rates were obtained from low molecular weight PDLLA-prepared particles which degraded faster.

Original languageEnglish (US)
JournalArtificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume22
Issue number5
Publication statusPublished - Nov 1994

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomedical Engineering

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