Polymorphism of Qa and Tla loci of the mouse

SNEH TEWARSON, ZOFIA ZALESKA‐RUTCZYNSKA, FELIPE FIGUEROA, JAN KLEIN

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Abstract

Congenic lines carrying H‐2 haplotypes derived from wild mice were typed serologically with polyclonal and monoclonal antibodies specific for Tla, Qa‐1, and Qa‐2 antigens. The typing revealed the presence of a minimum of five Tla, four Qa‐1, and three Qa‐2 alleles in the 32 lines. Two new Tla, two new Qa‐1, and one new Qa‐2 alleles could be described. This polymorphism of Tla and Qa loci is lower than that detected at the K and D loci in the same lines. The serological typing for Qa‐2 antigens correlates remarkably well with previously published results of typing with cytolytic T lymphocytes. This correlation supports the identity of loci detected by the two methods.

Original languageEnglish (US)
Pages (from-to)204-212
Number of pages9
JournalTissue Antigens
Volume22
Issue number3
DOIs
Publication statusPublished - Sep 1983

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

TEWARSON, SNEH., ZALESKA‐RUTCZYNSKA, ZOFIA., FIGUEROA, FELIPE., & KLEIN, JAN. (1983). Polymorphism of Qa and Tla loci of the mouse. Tissue Antigens, 22(3), 204-212. https://doi.org/10.1111/j.1399-0039.1983.tb01193.x