Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance

Zachary Simmons, Mark B. Bromberg, Eva L. Feldman, Mila Blaivas

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Although polyneuropathies associated with IgM and IgG monoclonal gammopathies have been well described, polyneuropathy with IgA monoclonal gammopathy of undetermined significance (MGUS) is less commonly seen and has not been well studies. We reviewed the clinical and electrodiagnostic features of 5 such patients, and the sural nerve biopsy findings in 4 of them. One patient was diabetic, while 4 were free of other diagnoses commonly associated with neuropathy. Clinical presentations were varied. Electrodiagnostic and histological studies ranged from primary demyelination to primary axon loss to a mixed axonal/demyelinating picture. Three patients who were treated appeared to respond to prednisone or intravenous gamma globulin, despite clear clinical, electrodiagnostic, and histological differences. We conclude that the polyneuropathy associated with IgA MGUS is heterogeneous, similar to that in IgM and IgG MGUS. A trial of immunomodulating therapy appears to be warranted in such patients if the neuropathy is sufficiently servere. © 1993 John Wiley & Sons, Inc.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalMuscle & nerve
Volume16
Issue number1
DOIs
StatePublished - Jan 1993

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Monoclonal Gammopathy of Undetermined Significance
Polyneuropathies
Immunoglobulin A
Immunoglobulin M
Immunoglobulin G
Sural Nerve
Paraproteinemias
gamma-Globulins
Demyelinating Diseases
Prednisone
Nuclear Family
Axons
Biopsy

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Simmons, Zachary ; Bromberg, Mark B. ; Feldman, Eva L. ; Blaivas, Mila. / Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance. In: Muscle & nerve. 1993 ; Vol. 16, No. 1. pp. 77-83.
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Polyneuropathy associated with IgA monoclonal gammopathy of undetermined significance. / Simmons, Zachary; Bromberg, Mark B.; Feldman, Eva L.; Blaivas, Mila.

In: Muscle & nerve, Vol. 16, No. 1, 01.1993, p. 77-83.

Research output: Contribution to journalArticle

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AB - Although polyneuropathies associated with IgM and IgG monoclonal gammopathies have been well described, polyneuropathy with IgA monoclonal gammopathy of undetermined significance (MGUS) is less commonly seen and has not been well studies. We reviewed the clinical and electrodiagnostic features of 5 such patients, and the sural nerve biopsy findings in 4 of them. One patient was diabetic, while 4 were free of other diagnoses commonly associated with neuropathy. Clinical presentations were varied. Electrodiagnostic and histological studies ranged from primary demyelination to primary axon loss to a mixed axonal/demyelinating picture. Three patients who were treated appeared to respond to prednisone or intravenous gamma globulin, despite clear clinical, electrodiagnostic, and histological differences. We conclude that the polyneuropathy associated with IgA MGUS is heterogeneous, similar to that in IgM and IgG MGUS. A trial of immunomodulating therapy appears to be warranted in such patients if the neuropathy is sufficiently servere. © 1993 John Wiley & Sons, Inc.

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