Polyphosphazene-hydroxyapatite composites as scaffolds for bone tissue engineering

S. Lakshmi, Y. E. Greish, J. W. Freeman, J. D. Bender, P. W. Brown, H. R. Allcock, C. T. Laurencin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A method that enables the synthesis of bone like apatites at physiological conditions through a cement-like reaction from hydroxyapatite precursors (HAp) such as tetracalcium phosphate (TetCP) and dicalcium phosphate (DCPA), was presented. The feasibility of developing HAp-biodegradable polyphosphazenes composites as suitable materials for bone tissue engineering were demonstrated. X-ray diffraction analysis of the HAp and composites were performed using an automated diffractometer, and the changes in mechanical properties were recorded. It was found that the incorporation of polyphosphazenes significantly improves cell adhesion and proliferation on the composites.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Fingerprint Dive into the research topics of 'Polyphosphazene-hydroxyapatite composites as scaffolds for bone tissue engineering'. Together they form a unique fingerprint.

  • Cite this

    Lakshmi, S., Greish, Y. E., Freeman, J. W., Bender, J. D., Brown, P. W., Allcock, H. R., & Laurencin, C. T. (2004). Polyphosphazene-hydroxyapatite composites as scaffolds for bone tissue engineering. In Transactions - 7th World Biomaterials Congress (Transactions - 7th World Biomaterials Congress).