Polyphosphazenes as biomaterials

Meng Deng, Cato T. Laurencin, Harry R. Allcock, Sangamesh G. Kumbar

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Biomaterials are generally “substances other than food or drugs contained in therapeutic or diagnostic systems that are in contact with tissue or biological ¥uids” (Langer and Peppas 2003). Synthetic or natural materials are thus designed to interface with biology and have been widely used for a number of biomedical applications including drug delivery devices, temporary prostheses, and tissue engineering scaffolds (Langer and Peppas 2003; Ratner and Bryant 2004). In controlled drug delivery, a biodegradable matrix that can be loaded with different biologically active molecules is preferred to release various therapeutic agents in an erosion-or diffusion-controlled fashion or a combination of both. For tissue engineering applications, a three-dimensional (3D) biodegradable scaffold that mimics the properties of various tissues is required to support cellular activities and promote neo-tissue formation. Even though biomaterials have already contributed greatly to the improvement of human health, the need for better biomaterial systems is still increasing (Ratner and Bryant 2004).

Original languageEnglish (US)
Title of host publicationPolymeric Biomaterials
Subtitle of host publicationStructure and Function
PublisherCRC Press
Pages84-126
Number of pages43
Volume1
ISBN (Electronic)9781420094718
ISBN (Print)9781420094701
DOIs
StatePublished - Jan 1 2013

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All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Materials Science(all)
  • Chemistry(all)

Cite this

Deng, M., Laurencin, C. T., Allcock, H. R., & Kumbar, S. G. (2013). Polyphosphazenes as biomaterials. In Polymeric Biomaterials: Structure and Function (Vol. 1, pp. 84-126). CRC Press. https://doi.org/10.1201/b13757