Polytene chromosomal maps of 11 drosophila species: The order of genomic scaffolds inferred from genetic and physical maps

Stephen W. Schaeffer, Arjun Bhutkar, Bryant F. McAllister, Muneo Matsuda, Luciano M. Matzkin, Patrick M. O'Grady, Claudia Rohde, Vera L.S. Valente, Montserrat Aguadé, Wyatt W. Anderson, Kevin Edwards, Ana C.L. Garcia, Josh Goodman, James Hartigan, Eiko Kataoka, Richard T. Lapoint, Elena R. Lozovsky, Carlos A. Machado, Mohamed A.F. Noor, Montserrat PapaceitLaura K. Reed, Stephen Richards, Tania T. Rieger, Susan M. Russo, Hajime Sato, Carmen Segarra, Douglas R. Smith, Temple F. Smith, Victor Strelets, Yoshiko N. Tobari, Yoshihiko Tomimura, Marvin Wasserman, Thomas Watts, Robert Wilson, Kiyohito Yoshida, Therese A. Markow, William M. Gelbart, Thomas C. Kaufman

Research output: Contribution to journalArticlepeer-review

135 Scopus citations

Abstract

The sequencing of the 12 genomes of members of the genus Drosophila was taken as an opportunity to reevaluate the genetic and physical maps for 11 of the species, in part to aid in the mapping of assembled scaffolds. Here, we present an overview of the importance of cytogenetic maps to Drosophila biology and to the concepts of chromosomal evolution. Physical and genetic markers were used to anchor the genome assembly scaffolds to the polytene chromosomal maps for each species. In addition, a computational approach was used to anchor smaller scaffolds on the basis of the analysis of syntenic blocks. We present the chromosomal map data from each of the 11 sequenced non-Drosophila melanogaster species as a series of sections. Each section reviews the history of the polytene chromosome maps for each species, presents the new polytene chromosome maps, and anchors the genomic scaffolds to the cytological maps using genetic and physical markers. The mapping data agree with Muller's idea that the majority of Drosophila genes are syntenic. Despite the conservation of genes within homologous chromosome arms across species, the karyotypes of these species have changed through the fusion of chromosomal arms followed by subsequent rearrangement events.

Original languageEnglish (US)
Pages (from-to)1601-1655
Number of pages55
JournalGenetics
Volume179
Issue number3
DOIs
StatePublished - Jul 2008

All Science Journal Classification (ASJC) codes

  • Genetics

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