Polyurethanes in cardiac device leads: Effect of morphology on performance

Aiay D. Padsalgikar, Genevieve Gallagher, Elizabeth Cosgriff-Hernandez, James Runt

Research output: Contribution to conferencePaper

Abstract

Implantable thermoplastic polyurethanes (TPU) have been utilized in the medical industry for decades due to their combination of biocompatibility, abrasion resistance, and processability. The present review attempts to establish the main factors that affect the long term biostability of TPUs, based upon multiple in vitro and in vivo studies. TPUs present two main degradation modes: oxidation and hydrolysis, which accelerate under mechanical stress. Siloxane-based TPUs seem to be most resistant to biological degradation. In addition, their complex morphology makes accelerated in vitro predictions based on time-temperature superposition inaccurate.

Original languageEnglish (US)
Pages1893-1899
Number of pages7
StatePublished - Jan 1 2014
Event72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014 - Las Vegas, United States
Duration: Apr 28 2014Apr 30 2014

Other

Other72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014
CountryUnited States
CityLas Vegas
Period4/28/144/30/14

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Polymers and Plastics

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  • Cite this

    Padsalgikar, A. D., Gallagher, G., Cosgriff-Hernandez, E., & Runt, J. (2014). Polyurethanes in cardiac device leads: Effect of morphology on performance. 1893-1899. Paper presented at 72nd Annual Technical Conference of the Society of Plastics Engineers: The Plastics Conference, ANTEC 2014, Las Vegas, United States.