Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus

De Feng Huang, Katherine A. Siminovitch, Xiao Yuan Liu, Tsaiwei Olee, Nancy J. Olsen, Charles Berry, Dennis A. Carson, Pojen P. Chen

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Abstract

The contribution to systemic lupus erythematosus (SLE) of three lupus- associated polymorphisms (involving the C4A2 complement component, Humhv3005 and the T cell antigen receptor alpha chain gene) are investigated in 81 individuals from 14 multiplex SLE families, 41 unrelated lupus patients, and 88 unrelated healthy controls. The results show a strong association between C4A deletion and SLE in these families. While the current study confirms the previously reported association between hv3005 deletion and sporadic SLE, the study fails to support this association in familial SLE patients. Moreover, no correlation is detected between the occurrence of hv3005 deletion and C4A null alleles in lupus patients, suggesting that the effects of these genetic polymorphisms on predisposition to lupus are independent. The previously reported lupus-associated T cell receptor (TCR) α chain polymorphism is not detected in any of the individuals studied here. The combined data suggest that C4A null alleles predispose strongly to development of lupus, whereas the influence of hv3005 deletion is relatively weak. The results also suggest that contributions of weak susceptibility genes such as hv3005 to disease predisposition may be obscured by the effects of stronger genetic factors and thus need to be examined in patients lacking these factors.

Original languageEnglish (US)
Pages (from-to)1766-1772
Number of pages7
JournalJournal of Clinical Investigation
Volume95
Issue number4
DOIs
StatePublished - Apr 1995

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Huang, D. F., Siminovitch, K. A., Liu, X. Y., Olee, T., Olsen, N. J., Berry, C., Carson, D. A., & Chen, P. P. (1995). Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. Journal of Clinical Investigation, 95(4), 1766-1772. https://doi.org/10.1172/JCI117854