Population genetics of the murine chromosome 17. Elisabeth Goldschmidt Memorial Lecture

J. Klein

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

In the house mouse, Mus musculus L., chromosome No. 17 is short, representing only about 3.5% of the total length of the haploid mitotic complement. In terms of genetic distance, its total length is about 30 cM. The chromosome carries a terminal or subterminal centromere and is characterized on Giemsa-banded preparation by a conspicuous gap in its centromeric half and six approximately equal bands, interspersed with four more or less gaps, excluding the large gap. Estimating the total number of loci in the mammalian genome at about 4x104, one can calculate the number of loci in chromosome 17 to be roughly 1,400. Of these loci, only about 30 have been identified. The known loci can be grouped into four categories according to their phenotypic effect: loci that affect both lymphocyte differentiation and complement activity [the histocompatibility-2 (H-2) complex]; loci that control embryonic and sperm differentiation (the t complex); loci that control hair growth (tf and thf); and loci that code for isozymes (Glo-1, Apl, Map-2, Pgk-2, and Ce-2). Two complex systems, H-2 and t, which contain some of the most intensively studied genes of the mouse genome, are discussed.

Original languageEnglish (US)
Pages (from-to)859-866
Number of pages8
JournalIsrael Journal of Medical Sciences
Volume15
Issue number10
StatePublished - Dec 1 1979

All Science Journal Classification (ASJC) codes

  • Bioengineering

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