Population-level antibody estimates to novel influenza A/H7N9

Maciej F. Boni, Nguyen Van Vinh Chau, Nguyen Dong, Stacy Todd, Nguyen Thi Duy Nhat, Erwin De Bruin, Janko Van Beek, Nguyen Tran Hien, Cameron P. Simmons, Jeremy Farrar, Marion Koopmans

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

There are no contemporary data available describing human immunity to novel influenza A/H7N9. Using 1723 prospectively collected serum samples in southern Vietnam, we tested for antibodies to 5 avian influenza virus antigens, using a protein microarray. General-population antibody titers against subtype H7 virus are higher than antibody titers against subtype H5 and lower than titers against H9. The highest titers were observed for human influenza virus subtypes. Titers to avian influenza virus antigens increased with age and with geometric mean antibody titer to human influenza virus antigens. There were no titer differences between the urban and the rural location in our study.

Original languageEnglish (US)
Pages (from-to)554-558
Number of pages5
JournalJournal of Infectious Diseases
Volume208
Issue number4
DOIs
StatePublished - Aug 15 2013

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Orthomyxoviridae
Human Influenza
Influenza in Birds
Antibodies
Antigens
Population
Protein Array Analysis
Vietnam
Immunity
Viruses
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Boni, M. F., Van Vinh Chau, N., Dong, N., Todd, S., Nhat, N. T. D., De Bruin, E., ... Koopmans, M. (2013). Population-level antibody estimates to novel influenza A/H7N9. Journal of Infectious Diseases, 208(4), 554-558. https://doi.org/10.1093/infdis/jit224
Boni, Maciej F. ; Van Vinh Chau, Nguyen ; Dong, Nguyen ; Todd, Stacy ; Nhat, Nguyen Thi Duy ; De Bruin, Erwin ; Van Beek, Janko ; Hien, Nguyen Tran ; Simmons, Cameron P. ; Farrar, Jeremy ; Koopmans, Marion. / Population-level antibody estimates to novel influenza A/H7N9. In: Journal of Infectious Diseases. 2013 ; Vol. 208, No. 4. pp. 554-558.
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Boni, MF, Van Vinh Chau, N, Dong, N, Todd, S, Nhat, NTD, De Bruin, E, Van Beek, J, Hien, NT, Simmons, CP, Farrar, J & Koopmans, M 2013, 'Population-level antibody estimates to novel influenza A/H7N9', Journal of Infectious Diseases, vol. 208, no. 4, pp. 554-558. https://doi.org/10.1093/infdis/jit224

Population-level antibody estimates to novel influenza A/H7N9. / Boni, Maciej F.; Van Vinh Chau, Nguyen; Dong, Nguyen; Todd, Stacy; Nhat, Nguyen Thi Duy; De Bruin, Erwin; Van Beek, Janko; Hien, Nguyen Tran; Simmons, Cameron P.; Farrar, Jeremy; Koopmans, Marion.

In: Journal of Infectious Diseases, Vol. 208, No. 4, 15.08.2013, p. 554-558.

Research output: Contribution to journalArticle

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Boni MF, Van Vinh Chau N, Dong N, Todd S, Nhat NTD, De Bruin E et al. Population-level antibody estimates to novel influenza A/H7N9. Journal of Infectious Diseases. 2013 Aug 15;208(4):554-558. https://doi.org/10.1093/infdis/jit224