Pore-forming proteins and adaptation of living organisms to environmental conditions

Zh I. Andreeva-Kovalevskaya, A. S. Solonin, E. V. Sineva, V. I. Ternovsky

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Pore-forming proteins are powerful "tools" for adaptation of living organisms to environmental conditions. A wide range of these proteins isolated from various sources, from viruses to mammals, has been used for the analysis of their role in the processes of intra- and inter-species competition, defense, attack, and signaling. Here we review a large number of pore-forming proteins from the perspective of their functions, structures, and mechanisms of membrane penetration. Various mechanisms of cell damage, executed by these proteins in the course of formation of a pore and after its passing to conducting state, have been considered: endo- and exocytosis, lysis, necrosis, apoptosis, etc. The role of pore-forming proteins in evolution is discussed. The relevance of practical application of pore formers has been shown, including application in nanotechnological constructions.

Original languageEnglish (US)
Pages (from-to)1473-1492
Number of pages20
JournalBiochemistry (Moscow)
Volume73
Issue number13
DOIs
StatePublished - Dec 1 2008

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Porins
Proteins
Exocytosis
Endocytosis
Mammals
Necrosis
Apoptosis
Viruses
Membranes
Cells

All Science Journal Classification (ASJC) codes

  • Biochemistry

Cite this

Andreeva-Kovalevskaya, Z. I., Solonin, A. S., Sineva, E. V., & Ternovsky, V. I. (2008). Pore-forming proteins and adaptation of living organisms to environmental conditions. Biochemistry (Moscow), 73(13), 1473-1492. https://doi.org/10.1134/S0006297908130087
Andreeva-Kovalevskaya, Zh I. ; Solonin, A. S. ; Sineva, E. V. ; Ternovsky, V. I. / Pore-forming proteins and adaptation of living organisms to environmental conditions. In: Biochemistry (Moscow). 2008 ; Vol. 73, No. 13. pp. 1473-1492.
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Andreeva-Kovalevskaya, ZI, Solonin, AS, Sineva, EV & Ternovsky, VI 2008, 'Pore-forming proteins and adaptation of living organisms to environmental conditions', Biochemistry (Moscow), vol. 73, no. 13, pp. 1473-1492. https://doi.org/10.1134/S0006297908130087

Pore-forming proteins and adaptation of living organisms to environmental conditions. / Andreeva-Kovalevskaya, Zh I.; Solonin, A. S.; Sineva, E. V.; Ternovsky, V. I.

In: Biochemistry (Moscow), Vol. 73, No. 13, 01.12.2008, p. 1473-1492.

Research output: Contribution to journalArticle

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