Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis

Jonathan G. Stine, Puja M. Shah, Scott L. Cornella, Sean R. Rudnick, Marwan S. Ghabril, George J. Stukenborg, Patrick G. Northup

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations (variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis. METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI. RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality (OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites (OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed.

Original languageEnglish (US)
Pages (from-to)2774-2780
Number of pages7
JournalWorld Journal of Hepatology
Volume7
Issue number27
DOIs
StatePublished - Jan 1 2015

Fingerprint

Portal Vein
Meta-Analysis
Thrombosis
Fibrosis
Ascites
Hepatic Encephalopathy
Mortality
Liver
Hemorrhage
Literature
MEDLINE
Libraries
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Stine, J. G., Shah, P. M., Cornella, S. L., Rudnick, S. R., Ghabril, M. S., Stukenborg, G. J., & Northup, P. G. (2015). Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis. World Journal of Hepatology, 7(27), 2774-2780. https://doi.org/10.4254/wjh.v7.i27.2774
Stine, Jonathan G. ; Shah, Puja M. ; Cornella, Scott L. ; Rudnick, Sean R. ; Ghabril, Marwan S. ; Stukenborg, George J. ; Northup, Patrick G. / Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis : A meta-analysis. In: World Journal of Hepatology. 2015 ; Vol. 7, No. 27. pp. 2774-2780.
@article{261687ed88f246c790cd28c6dc932b7f,
title = "Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis",
abstract = "AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations (variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis. METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95{\%}CI. RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality (OR = 1.62, 95{\%}CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites (OR = 2.52, 95{\%}CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed.",
author = "Stine, {Jonathan G.} and Shah, {Puja M.} and Cornella, {Scott L.} and Rudnick, {Sean R.} and Ghabril, {Marwan S.} and Stukenborg, {George J.} and Northup, {Patrick G.}",
year = "2015",
month = "1",
day = "1",
doi = "10.4254/wjh.v7.i27.2774",
language = "English (US)",
volume = "7",
pages = "2774--2780",
journal = "World Journal of Hepatology",
issn = "1948-5182",
publisher = "Baishideng Publishing Group",
number = "27",

}

Stine, JG, Shah, PM, Cornella, SL, Rudnick, SR, Ghabril, MS, Stukenborg, GJ & Northup, PG 2015, 'Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis: A meta-analysis', World Journal of Hepatology, vol. 7, no. 27, pp. 2774-2780. https://doi.org/10.4254/wjh.v7.i27.2774

Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis : A meta-analysis. / Stine, Jonathan G.; Shah, Puja M.; Cornella, Scott L.; Rudnick, Sean R.; Ghabril, Marwan S.; Stukenborg, George J.; Northup, Patrick G.

In: World Journal of Hepatology, Vol. 7, No. 27, 01.01.2015, p. 2774-2780.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Portal vein thrombosis, mortality and hepatic decompensation in patients with cirrhosis

T2 - A meta-analysis

AU - Stine, Jonathan G.

AU - Shah, Puja M.

AU - Cornella, Scott L.

AU - Rudnick, Sean R.

AU - Ghabril, Marwan S.

AU - Stukenborg, George J.

AU - Northup, Patrick G.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations (variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis. METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI. RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality (OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites (OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed.

AB - AIM: To determine the clinical impact of portal vein thrombosis in terms of both mortality and hepatic decompensations (variceal hemorrhage, ascites, portosystemic encephalopathy) in adult patients with cirrhosis. METHODS: We identified original articles reported through February 2015 in MEDLINE, Scopus, Science Citation Index, AMED, the Cochrane Library, and relevant examples available in the grey literature. Two independent reviewers screened all citations for inclusion criteria and extracted summary data. Random effects odds ratios were calculated to obtain aggregate estimates of effect size across included studies, with 95%CI. RESULTS: A total of 226 citations were identified and reviewed, and 3 studies with 2436 participants were included in the meta-analysis of summary effect. Patients with portal vein thrombosis had an increased risk of mortality (OR = 1.62, 95%CI: 1.11-2.36, P = 0.01). Portal vein thrombosis was associated with an increased risk of ascites (OR = 2.52, 95%CI: 1.63-3.89, P < 0.001). There was insufficient data available to determine the pooled effect on other markers of decompensation including gastroesophageal variceal bleeding or hepatic encephalopathy. CONCLUSION: Portal vein thrombosis appears to increase mortality and ascites, however, the relatively small number of included studies limits more generalizable conclusions. More trials with a direct comparison group are needed.

UR - http://www.scopus.com/inward/record.url?scp=84949599613&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949599613&partnerID=8YFLogxK

U2 - 10.4254/wjh.v7.i27.2774

DO - 10.4254/wjh.v7.i27.2774

M3 - Article

C2 - 26644821

AN - SCOPUS:84949599613

VL - 7

SP - 2774

EP - 2780

JO - World Journal of Hepatology

JF - World Journal of Hepatology

SN - 1948-5182

IS - 27

ER -