Positive and negative chemotaxis of enzyme-coated liposome motors

Ambika Somasundar, Subhadip Ghosh, Farzad Mohajerani, Lynnicia N. Massenburg, Tinglu Yang, Paul S. Cremer, Darrell Velegol, Ayusman Sen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The ability of cells or cell components to move in response to chemical signals is critical for the survival of living systems. This motion arises from harnessing free energy from enzymatic catalysis. Artificial model protocells derived from phospholipids and other amphiphiles have been made and their enzymatic-driven motion has been observed. However, control of directionality based on chemical cues (chemotaxis) has been difficult to achieve. Here we show both positive or negative chemotaxis of liposomal protocells. The protocells move autonomously by interacting with concentration gradients of either substrates or products in enzyme catalysis, or Hofmeister salts. We hypothesize that the propulsion mechanism is based on the interplay between enzyme-catalysis-induced positive chemotaxis and solute–phospholipid-based negative chemotaxis. Controlling the extent and direction of chemotaxis holds considerable potential for designing cell mimics and delivery vehicles that can reconfigure their motion in response to environmental conditions.

Original languageEnglish (US)
Pages (from-to)1129-1134
Number of pages6
JournalNature nanotechnology
Volume14
Issue number12
DOIs
StatePublished - Dec 1 2019

Fingerprint

Liposomes
Catalysis
catalysis
enzymes
Enzymes
cells
Amphiphiles
Phospholipids
cues
propulsion
Propulsion
Free energy
delivery
vehicles
Salts
free energy
salts
gradients
Substrates
products

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • Materials Science(all)
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

Cite this

Somasundar, Ambika ; Ghosh, Subhadip ; Mohajerani, Farzad ; Massenburg, Lynnicia N. ; Yang, Tinglu ; Cremer, Paul S. ; Velegol, Darrell ; Sen, Ayusman. / Positive and negative chemotaxis of enzyme-coated liposome motors. In: Nature nanotechnology. 2019 ; Vol. 14, No. 12. pp. 1129-1134.
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Positive and negative chemotaxis of enzyme-coated liposome motors. / Somasundar, Ambika; Ghosh, Subhadip; Mohajerani, Farzad; Massenburg, Lynnicia N.; Yang, Tinglu; Cremer, Paul S.; Velegol, Darrell; Sen, Ayusman.

In: Nature nanotechnology, Vol. 14, No. 12, 01.12.2019, p. 1129-1134.

Research output: Contribution to journalArticle

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