Positive CSF HSV PCR in patients with GBM: A note of caution

S. S. McDermott, P. F. McDermott, J. Skare, Michael Glantz, T. W. Smith, N. S. Litofsky, Lawrence D. Recht

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Because two patients with temporal lobe glioblastomas had herpes simplex (HSV) DNA detected in CSF using PCR at the time of their presentation, we reviewed our laboratory's experience and performed PCR on a bank of 159 frozen CSF samples from patients with glioblastoma multiforme and other neurologic disorders. Based on the inability to detect HSV in any other tumor sample, we conclude that the positive HSV PCR in our two index patients most likely represented false-positive results. A diagnosis of HSE should not be made by PCR alone when the clinical presentation is atypical.

Original languageEnglish (US)
Pages (from-to)746-749
Number of pages4
JournalNeurology
Volume54
Issue number3
StatePublished - Feb 8 2000

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Polymerase Chain Reaction
Glioblastoma
Herpes Simplex
Temporal Lobe
Nervous System Diseases
DNA
Neoplasms

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

McDermott, S. S., McDermott, P. F., Skare, J., Glantz, M., Smith, T. W., Litofsky, N. S., & Recht, L. D. (2000). Positive CSF HSV PCR in patients with GBM: A note of caution. Neurology, 54(3), 746-749.
McDermott, S. S. ; McDermott, P. F. ; Skare, J. ; Glantz, Michael ; Smith, T. W. ; Litofsky, N. S. ; Recht, Lawrence D. / Positive CSF HSV PCR in patients with GBM : A note of caution. In: Neurology. 2000 ; Vol. 54, No. 3. pp. 746-749.
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McDermott, SS, McDermott, PF, Skare, J, Glantz, M, Smith, TW, Litofsky, NS & Recht, LD 2000, 'Positive CSF HSV PCR in patients with GBM: A note of caution', Neurology, vol. 54, no. 3, pp. 746-749.

Positive CSF HSV PCR in patients with GBM : A note of caution. / McDermott, S. S.; McDermott, P. F.; Skare, J.; Glantz, Michael; Smith, T. W.; Litofsky, N. S.; Recht, Lawrence D.

In: Neurology, Vol. 54, No. 3, 08.02.2000, p. 746-749.

Research output: Contribution to journalArticle

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McDermott SS, McDermott PF, Skare J, Glantz M, Smith TW, Litofsky NS et al. Positive CSF HSV PCR in patients with GBM: A note of caution. Neurology. 2000 Feb 8;54(3):746-749.