Positive panel reactive antibody titers in patients bridged to transplantation with a mechanical assist device: Risk factors and treatment

Pei H. Tsau, Francisco A. Arabía, Bruce Toporoff, Venki Paramesh, Gulshan K. Sethi, Jack G. Copeland

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Patients who are bridged-to-transplantation with mechanical support have a high incidence of pretransplant sensitization defined by panel reactive antibody (PRA) titers greater than 10. Risk factors for positive PRA in patients with assist devices were investigated. It is recommended that patients who are bridged-to-transplantation with assist devices and have high PRA levels be treated with perioperative plasmapheresis. With this aggressive approach, it may no longer be necessary to keep patients on mechanical support for prolonged periods, but possible to perform transplants as soon as suitable donors become available.

Original languageEnglish (US)
JournalASAIO Journal
Volume44
Issue number5
DOIs
StatePublished - Jan 1 1998

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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