Positive patch-test reactions to propylene glycol

A retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006

Erin M. Warshaw, Nina C. Botto, Howard I. Maibach, Joseph F. Fowler, Robert L. Rietschel, Kathryn A. Zug, Donald V. Belsito, James S. Taylor, Vincent A. DeLeo, Melanie D. Pratt, Denis Sasseville, Frances J. Storrs, James Marks, C. G.Toby Mathias

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Propylene glycol (PG) may cause allergic or irritant contact dermatitis. It primarily functions as a vehicle, solvent, or emulsifier in cosmetics and topical medications. Objectives: To characterize the prevalence of positive patch-test reactions to PG and the epidemiology of affected patients. Methods: Retrospective analysis of cross-sectional data compiled by the North American Contact Dermatitis Group (NACDG) from 1996 to 2006. Results: Of 23,359 patients, 810 (3.5%) had allergic patch-test reactions to 30% PG; 12.8% of the reactions were of definite clinical relevance (positive reaction to a personal product containing PG), 88.3% were considered to be currently relevant (definite, probable, or possible relevance), and 4.2% of reactions were occupation related, most commonly to mechanical and motor vehicle occupations. Common sources of PG were personal care products (creams, lotions, and cosmetics, 53.8%), topical corticosteroids (18.3%), and other topical medicaments (10.1%). In patients positive only to PG (n = 135), the face was most commonly affected (25.9%), followed by a scattered or generalized pattern (23.7%). The most common concomitant reactions included reactions to Myroxilon pereirae, fragrance mix, formaldehyde, bacitracin, methyldibromoglutaronitrile/ phenoxyethanol, carba mix, and tixocortol pivalate. Conclusions: In this select population of patients referred for patch testing, allergic reactions to PG were often currently clinically relevant but were rarely related to occupation. The most common sources were personal care products and topical corticosteroids.

Original languageEnglish (US)
Pages (from-to)14-20
Number of pages7
JournalDermatitis
Volume20
Issue number1
DOIs
StatePublished - Feb 1 2009

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Propylene Glycol
Patch Tests
Contact Dermatitis
Cross-Sectional Studies
Occupations
Cosmetics
Adrenal Cortex Hormones
Irritant Dermatitis
Bacitracin
Motor Vehicles
Formaldehyde
Hypersensitivity
Epidemiology
Population

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Dermatology

Cite this

Warshaw, E. M., Botto, N. C., Maibach, H. I., Fowler, J. F., Rietschel, R. L., Zug, K. A., ... Mathias, C. G. T. (2009). Positive patch-test reactions to propylene glycol: A retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006. Dermatitis, 20(1), 14-20. https://doi.org/10.2310/6620.2008.08039
Warshaw, Erin M. ; Botto, Nina C. ; Maibach, Howard I. ; Fowler, Joseph F. ; Rietschel, Robert L. ; Zug, Kathryn A. ; Belsito, Donald V. ; Taylor, James S. ; DeLeo, Vincent A. ; Pratt, Melanie D. ; Sasseville, Denis ; Storrs, Frances J. ; Marks, James ; Mathias, C. G.Toby. / Positive patch-test reactions to propylene glycol : A retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006. In: Dermatitis. 2009 ; Vol. 20, No. 1. pp. 14-20.
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abstract = "Background: Propylene glycol (PG) may cause allergic or irritant contact dermatitis. It primarily functions as a vehicle, solvent, or emulsifier in cosmetics and topical medications. Objectives: To characterize the prevalence of positive patch-test reactions to PG and the epidemiology of affected patients. Methods: Retrospective analysis of cross-sectional data compiled by the North American Contact Dermatitis Group (NACDG) from 1996 to 2006. Results: Of 23,359 patients, 810 (3.5{\%}) had allergic patch-test reactions to 30{\%} PG; 12.8{\%} of the reactions were of definite clinical relevance (positive reaction to a personal product containing PG), 88.3{\%} were considered to be currently relevant (definite, probable, or possible relevance), and 4.2{\%} of reactions were occupation related, most commonly to mechanical and motor vehicle occupations. Common sources of PG were personal care products (creams, lotions, and cosmetics, 53.8{\%}), topical corticosteroids (18.3{\%}), and other topical medicaments (10.1{\%}). In patients positive only to PG (n = 135), the face was most commonly affected (25.9{\%}), followed by a scattered or generalized pattern (23.7{\%}). The most common concomitant reactions included reactions to Myroxilon pereirae, fragrance mix, formaldehyde, bacitracin, methyldibromoglutaronitrile/ phenoxyethanol, carba mix, and tixocortol pivalate. Conclusions: In this select population of patients referred for patch testing, allergic reactions to PG were often currently clinically relevant but were rarely related to occupation. The most common sources were personal care products and topical corticosteroids.",
author = "Warshaw, {Erin M.} and Botto, {Nina C.} and Maibach, {Howard I.} and Fowler, {Joseph F.} and Rietschel, {Robert L.} and Zug, {Kathryn A.} and Belsito, {Donald V.} and Taylor, {James S.} and DeLeo, {Vincent A.} and Pratt, {Melanie D.} and Denis Sasseville and Storrs, {Frances J.} and James Marks and Mathias, {C. G.Toby}",
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Warshaw, EM, Botto, NC, Maibach, HI, Fowler, JF, Rietschel, RL, Zug, KA, Belsito, DV, Taylor, JS, DeLeo, VA, Pratt, MD, Sasseville, D, Storrs, FJ, Marks, J & Mathias, CGT 2009, 'Positive patch-test reactions to propylene glycol: A retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006', Dermatitis, vol. 20, no. 1, pp. 14-20. https://doi.org/10.2310/6620.2008.08039

Positive patch-test reactions to propylene glycol : A retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006. / Warshaw, Erin M.; Botto, Nina C.; Maibach, Howard I.; Fowler, Joseph F.; Rietschel, Robert L.; Zug, Kathryn A.; Belsito, Donald V.; Taylor, James S.; DeLeo, Vincent A.; Pratt, Melanie D.; Sasseville, Denis; Storrs, Frances J.; Marks, James; Mathias, C. G.Toby.

In: Dermatitis, Vol. 20, No. 1, 01.02.2009, p. 14-20.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Positive patch-test reactions to propylene glycol

T2 - A retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006

AU - Warshaw, Erin M.

AU - Botto, Nina C.

AU - Maibach, Howard I.

AU - Fowler, Joseph F.

AU - Rietschel, Robert L.

AU - Zug, Kathryn A.

AU - Belsito, Donald V.

AU - Taylor, James S.

AU - DeLeo, Vincent A.

AU - Pratt, Melanie D.

AU - Sasseville, Denis

AU - Storrs, Frances J.

AU - Marks, James

AU - Mathias, C. G.Toby

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Background: Propylene glycol (PG) may cause allergic or irritant contact dermatitis. It primarily functions as a vehicle, solvent, or emulsifier in cosmetics and topical medications. Objectives: To characterize the prevalence of positive patch-test reactions to PG and the epidemiology of affected patients. Methods: Retrospective analysis of cross-sectional data compiled by the North American Contact Dermatitis Group (NACDG) from 1996 to 2006. Results: Of 23,359 patients, 810 (3.5%) had allergic patch-test reactions to 30% PG; 12.8% of the reactions were of definite clinical relevance (positive reaction to a personal product containing PG), 88.3% were considered to be currently relevant (definite, probable, or possible relevance), and 4.2% of reactions were occupation related, most commonly to mechanical and motor vehicle occupations. Common sources of PG were personal care products (creams, lotions, and cosmetics, 53.8%), topical corticosteroids (18.3%), and other topical medicaments (10.1%). In patients positive only to PG (n = 135), the face was most commonly affected (25.9%), followed by a scattered or generalized pattern (23.7%). The most common concomitant reactions included reactions to Myroxilon pereirae, fragrance mix, formaldehyde, bacitracin, methyldibromoglutaronitrile/ phenoxyethanol, carba mix, and tixocortol pivalate. Conclusions: In this select population of patients referred for patch testing, allergic reactions to PG were often currently clinically relevant but were rarely related to occupation. The most common sources were personal care products and topical corticosteroids.

AB - Background: Propylene glycol (PG) may cause allergic or irritant contact dermatitis. It primarily functions as a vehicle, solvent, or emulsifier in cosmetics and topical medications. Objectives: To characterize the prevalence of positive patch-test reactions to PG and the epidemiology of affected patients. Methods: Retrospective analysis of cross-sectional data compiled by the North American Contact Dermatitis Group (NACDG) from 1996 to 2006. Results: Of 23,359 patients, 810 (3.5%) had allergic patch-test reactions to 30% PG; 12.8% of the reactions were of definite clinical relevance (positive reaction to a personal product containing PG), 88.3% were considered to be currently relevant (definite, probable, or possible relevance), and 4.2% of reactions were occupation related, most commonly to mechanical and motor vehicle occupations. Common sources of PG were personal care products (creams, lotions, and cosmetics, 53.8%), topical corticosteroids (18.3%), and other topical medicaments (10.1%). In patients positive only to PG (n = 135), the face was most commonly affected (25.9%), followed by a scattered or generalized pattern (23.7%). The most common concomitant reactions included reactions to Myroxilon pereirae, fragrance mix, formaldehyde, bacitracin, methyldibromoglutaronitrile/ phenoxyethanol, carba mix, and tixocortol pivalate. Conclusions: In this select population of patients referred for patch testing, allergic reactions to PG were often currently clinically relevant but were rarely related to occupation. The most common sources were personal care products and topical corticosteroids.

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DO - 10.2310/6620.2008.08039

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