Possible antioxidant action of the Bcl-2 protein

K. Marshall, L. Ellerby, Hong-Gang Wang, J. C. Reed, D. E. Bredesen, O. I. Aruoma, B. Halliwell

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Reactive oxygen species (ROS) have been implicated as mediators of programmed cell death (PCD). PCD is involved in many physiological and pathological processes. The Bcl-2 protein suppresses various types of apoptotic and in some cases necrotic cell death. The Bcl-2 protein is located at sites of free radical generation such as mitochondria and endoplasmic reticulum. However, it's mechanism of action is unknown. It has been suggested the Bcl-2 protein may act via an antioxidant mechanism to prevent PCD. To determine whether the Bcl-2 protein itself has antioxidant properties we tested the purified protein directly in our assay systems. We compared the action of the Bcl-2 protein with that of well known antioxidant proteins: catalase, glutathione peroxidase and Superoxide dismutase. We conclude that, in our assay systems, Bcl-2 appears not to show any significant 02'", H2U2 or organic peroxide-removing activity when compared with the above proteins.

Original languageEnglish (US)
Pages (from-to)532S
JournalBiochemical Society transactions
Issue number4
StatePublished - 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry

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    Marshall, K., Ellerby, L., Wang, H-G., Reed, J. C., Bredesen, D. E., Aruoma, O. I., & Halliwell, B. (1996). Possible antioxidant action of the Bcl-2 protein. Biochemical Society transactions, 24(4), 532S. https://doi.org/10.1042/bst024532s