Possible mechanisms of the cancer-preventive activities of green tea

Chung S. Yang, Shengmin Sang, Joshua D. Lambert, Zhe Hou, Jihyeung Ju, Gang Lu

Research output: Contribution to journalReview article

82 Citations (Scopus)

Abstract

The cancer-preventive activities of tea and some tea constituents, such as caffeine and (-)-epigallocatechin-3-gallate (EGCG), have been demonstrated in animal models. The mechanisms of action of the tea constituents have been extensively investigated, but the mechanisms for the cancer-preventive activity of tea are not clearly understood. This chapter discusses some of the reported studies on the green tea polyphenol, EGCG, and the major issues in the interpretation of these data. Among the different activities of EGCG observed in cell culture systems, we need to select the physiologically relevant ones based on the biological importance of the target as well as the effective concentration and whether the reaction can take place in vivo because of the limited bioavailability of EGCG. We also need to distinguish between primary and subsequent events. Possible artifacts should be recognized. The cancer-preventive mechanisms need to be validated in animal models or human samples.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalMolecular Nutrition and Food Research
Volume50
Issue number2
DOIs
StatePublished - Feb 1 2006

Fingerprint

epigallocatechin
green tea
Tea
tea
neoplasms
Neoplasms
animal models
Animal Models
caffeine
bioavailability
Polyphenols
mechanism of action
polyphenols
Caffeine
cell culture
Artifacts
Biological Availability
Cell Culture Techniques
epigallocatechin gallate
sampling

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Food Science

Cite this

Yang, Chung S. ; Sang, Shengmin ; Lambert, Joshua D. ; Hou, Zhe ; Ju, Jihyeung ; Lu, Gang. / Possible mechanisms of the cancer-preventive activities of green tea. In: Molecular Nutrition and Food Research. 2006 ; Vol. 50, No. 2. pp. 170-175.
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Possible mechanisms of the cancer-preventive activities of green tea. / Yang, Chung S.; Sang, Shengmin; Lambert, Joshua D.; Hou, Zhe; Ju, Jihyeung; Lu, Gang.

In: Molecular Nutrition and Food Research, Vol. 50, No. 2, 01.02.2006, p. 170-175.

Research output: Contribution to journalReview article

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AU - Yang, Chung S.

AU - Sang, Shengmin

AU - Lambert, Joshua D.

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AU - Lu, Gang

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AB - The cancer-preventive activities of tea and some tea constituents, such as caffeine and (-)-epigallocatechin-3-gallate (EGCG), have been demonstrated in animal models. The mechanisms of action of the tea constituents have been extensively investigated, but the mechanisms for the cancer-preventive activity of tea are not clearly understood. This chapter discusses some of the reported studies on the green tea polyphenol, EGCG, and the major issues in the interpretation of these data. Among the different activities of EGCG observed in cell culture systems, we need to select the physiologically relevant ones based on the biological importance of the target as well as the effective concentration and whether the reaction can take place in vivo because of the limited bioavailability of EGCG. We also need to distinguish between primary and subsequent events. Possible artifacts should be recognized. The cancer-preventive mechanisms need to be validated in animal models or human samples.

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