Possible Reproductive Detriment in LSD Users

Cecil B. Jacobson, Cheston Berlin

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

One hundred forty women and their consorts, admitting to the use of lysergic acid diethylamide (LSD) prior to or during pregnancy were observed through 148 pregnancies. There were 83 live newborns; 8 had major congenital defects. There were 65 abortions; 53 therapeutic and 12 spontaneous. Four of 14 embryos from therapeutic abortions showed gross anomalies. Forty-three percent of first-trimester pregnancies ended in spontaneous abortions. Four of eight serial pregnancies resulted in defective embryos or infants. Eight of 12 women have been unable to conceive again over an 18-month period. The ingestion of other illicit drugs, the presence of infectious disease, and marginal maternal nutrition preclude a definitive correlation of increased reproductive risk with LSD ingestion. The presence of LSD ingestion, coupled with studies in animals and supported by DNA studies, suggests that LSD might be hazardous to human reproduction.

Original languageEnglish (US)
Pages (from-to)1367-1373
Number of pages7
JournalJAMA: The Journal of the American Medical Association
Volume222
Issue number11
DOIs
StatePublished - Dec 11 1972

Fingerprint

Lysergic Acid Diethylamide
Eating
Pregnancy
Embryonic Structures
Therapeutic Abortion
Street Drugs
Spontaneous Abortion
First Pregnancy Trimester
Reproduction
Communicable Diseases
Mothers
Newborn Infant
DNA
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Jacobson, Cecil B. ; Berlin, Cheston. / Possible Reproductive Detriment in LSD Users. In: JAMA: The Journal of the American Medical Association. 1972 ; Vol. 222, No. 11. pp. 1367-1373.
@article{78d371cc878844f6a38163b3a754bd74,
title = "Possible Reproductive Detriment in LSD Users",
abstract = "One hundred forty women and their consorts, admitting to the use of lysergic acid diethylamide (LSD) prior to or during pregnancy were observed through 148 pregnancies. There were 83 live newborns; 8 had major congenital defects. There were 65 abortions; 53 therapeutic and 12 spontaneous. Four of 14 embryos from therapeutic abortions showed gross anomalies. Forty-three percent of first-trimester pregnancies ended in spontaneous abortions. Four of eight serial pregnancies resulted in defective embryos or infants. Eight of 12 women have been unable to conceive again over an 18-month period. The ingestion of other illicit drugs, the presence of infectious disease, and marginal maternal nutrition preclude a definitive correlation of increased reproductive risk with LSD ingestion. The presence of LSD ingestion, coupled with studies in animals and supported by DNA studies, suggests that LSD might be hazardous to human reproduction.",
author = "Jacobson, {Cecil B.} and Cheston Berlin",
year = "1972",
month = "12",
day = "11",
doi = "10.1001/jama.1972.03210110013004",
language = "English (US)",
volume = "222",
pages = "1367--1373",
journal = "JAMA - Journal of the American Medical Association",
issn = "0002-9955",
publisher = "American Medical Association",
number = "11",

}

Possible Reproductive Detriment in LSD Users. / Jacobson, Cecil B.; Berlin, Cheston.

In: JAMA: The Journal of the American Medical Association, Vol. 222, No. 11, 11.12.1972, p. 1367-1373.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Possible Reproductive Detriment in LSD Users

AU - Jacobson, Cecil B.

AU - Berlin, Cheston

PY - 1972/12/11

Y1 - 1972/12/11

N2 - One hundred forty women and their consorts, admitting to the use of lysergic acid diethylamide (LSD) prior to or during pregnancy were observed through 148 pregnancies. There were 83 live newborns; 8 had major congenital defects. There were 65 abortions; 53 therapeutic and 12 spontaneous. Four of 14 embryos from therapeutic abortions showed gross anomalies. Forty-three percent of first-trimester pregnancies ended in spontaneous abortions. Four of eight serial pregnancies resulted in defective embryos or infants. Eight of 12 women have been unable to conceive again over an 18-month period. The ingestion of other illicit drugs, the presence of infectious disease, and marginal maternal nutrition preclude a definitive correlation of increased reproductive risk with LSD ingestion. The presence of LSD ingestion, coupled with studies in animals and supported by DNA studies, suggests that LSD might be hazardous to human reproduction.

AB - One hundred forty women and their consorts, admitting to the use of lysergic acid diethylamide (LSD) prior to or during pregnancy were observed through 148 pregnancies. There were 83 live newborns; 8 had major congenital defects. There were 65 abortions; 53 therapeutic and 12 spontaneous. Four of 14 embryos from therapeutic abortions showed gross anomalies. Forty-three percent of first-trimester pregnancies ended in spontaneous abortions. Four of eight serial pregnancies resulted in defective embryos or infants. Eight of 12 women have been unable to conceive again over an 18-month period. The ingestion of other illicit drugs, the presence of infectious disease, and marginal maternal nutrition preclude a definitive correlation of increased reproductive risk with LSD ingestion. The presence of LSD ingestion, coupled with studies in animals and supported by DNA studies, suggests that LSD might be hazardous to human reproduction.

UR - http://www.scopus.com/inward/record.url?scp=0015503456&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015503456&partnerID=8YFLogxK

U2 - 10.1001/jama.1972.03210110013004

DO - 10.1001/jama.1972.03210110013004

M3 - Article

C2 - 4564413

AN - SCOPUS:0015503456

VL - 222

SP - 1367

EP - 1373

JO - JAMA - Journal of the American Medical Association

JF - JAMA - Journal of the American Medical Association

SN - 0002-9955

IS - 11

ER -