Post-transcriptional regulation of glucocorticoid function

Faoud T. Ishmael, Cristiana Stellato

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Glucocorticoids (GCs) are corticosteroid hormones critically involved in the homeostatic control of stress and immune responses. Endogenous GCs generally tend to support the innate immune responses while inhibiting overexpressed adaptive immune responses. Synthetic GCs, given systemically or topically, are the first-line anti-inflammatory drug class prescribed in the treatment of the majority of chronic inflammatory and immune-mediated diseases. Regulation of gene transcription through the ligand-activated glucocorticoid receptor (GR) is the core mechanism of their anti-inflammatory action; however their regulatory function spans from early signaling-through non-genomic actions-to downstream post-translational modifications. The anti-inflammatory action of GCs is achieved also through post-transcriptional regulation (PTR) of gene expression, which modulates the rates of mRNA transport, decay and translation. The molecular mechanisms by which GC act on PTR are still ill-defined but studies aimed at their discovery have been increasing in the last decade, subsequent to definitive experimental evidences of the important pathogenic role of PTR in inflammatory responses. In this chapter we will review the growing data indicating that control of deregulated post-transcriptional pathways is a critical, yet underappreciated component of GCs' efficient anti-inflammatory action. A more detailed understanding of the molecular species and pathways by which GC regulate inflammation by post-transcriptional mechanisms may lead to novel anti-inflammatory strategies that could be pursued as a GC-independent therapeutic approach.

Original languageEnglish (US)
Title of host publicationPost-Transcriptional Mechanisms in Endocrine Regulation
PublisherSpringer International Publishing
Pages277-313
Number of pages37
ISBN (Electronic)9783319251240
ISBN (Print)9783319251226
DOIs
StatePublished - Jan 1 2015

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Glucocorticoids
Anti-Inflammatory Agents
Immune System Diseases
Glucocorticoid Receptors
RNA Stability
Gene Expression Regulation
Protein Biosynthesis
Adaptive Immunity
Transcription
Post Translational Protein Processing
Innate Immunity
Gene expression
Adrenal Cortex Hormones
Genes
Hormones
Ligands
Inflammation
Messenger RNA
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ishmael, F. T., & Stellato, C. (2015). Post-transcriptional regulation of glucocorticoid function. In Post-Transcriptional Mechanisms in Endocrine Regulation (pp. 277-313). Springer International Publishing. https://doi.org/10.1007/978-3-319-25124-0_13
Ishmael, Faoud T. ; Stellato, Cristiana. / Post-transcriptional regulation of glucocorticoid function. Post-Transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing, 2015. pp. 277-313
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Ishmael, FT & Stellato, C 2015, Post-transcriptional regulation of glucocorticoid function. in Post-Transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing, pp. 277-313. https://doi.org/10.1007/978-3-319-25124-0_13

Post-transcriptional regulation of glucocorticoid function. / Ishmael, Faoud T.; Stellato, Cristiana.

Post-Transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing, 2015. p. 277-313.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Ishmael FT, Stellato C. Post-transcriptional regulation of glucocorticoid function. In Post-Transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing. 2015. p. 277-313 https://doi.org/10.1007/978-3-319-25124-0_13