Post-transcriptional regulation of immunological responses through riboclustering

Koelina Ganguly, Jeevan Giddaluru, Avery August, Nooruddin Khan

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Immunological programing of immune cells varies in response to changing environmental signals. This process is facilitated by modifiers that regulate the translational fate of mRNAs encoding various immune mediators, including cytokines and chemokines, which in turn determine the rapid activation, tolerance, and plasticity of the immune system. RNA-binding proteins (RBPs) recruited by the specific sequence elements in mRNA transcripts are one such modifiers. These RBPs form RBP-RNA complexes known as "riboclusters." These riboclusters serve as RNA sorting machinery, where depending upon the composition of the ribocluster, translation, degradation, or storage of mRNA is controlled. Recent findings suggest that this regulation of mRNA homeostasis is critical for controlling the immune response. Here, we present the current knowledge of the ribocluster-mediated post-transcriptional regulation of immune mediators and highlight recent findings regarding their implications for the pathogenesis of acute or chronic inflammatory diseases.

Original languageEnglish (US)
Article number161
JournalFrontiers in immunology
Volume7
Issue numberAPR
DOIs
StatePublished - Apr 29 2016

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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