Post-transcriptional regulation of meprin α by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP)

Alanna N. Roff, Ronaldo P. Panganiban, Judith S. Bond, Faoud T. Ishmael

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Meprin α is a metalloproteinase implicated in the pathogenesis of inflammatory bowel disease (IBD). Results: RNA-binding proteins post-transcriptionally regulate meprin α, and RNA stability decreases after induction of an inflammatory response. Conclusion: Inflammatory stimuli downregulate meprin α by inducing TTP expression and binding to the transcript. Significance: Determining how inflammation alters meprin α regulation is crucial to understanding its role in IBD.

Original languageEnglish (US)
Pages (from-to)4733-4743
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
StatePublished - Feb 15 2013

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Tristetraprolin
ELAV Proteins
Tiopronin
RNA-Binding Proteins
Inflammatory Bowel Diseases
RNA Stability
Metalloproteases
Down-Regulation
RNA
Inflammation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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abstract = "Background: Meprin α is a metalloproteinase implicated in the pathogenesis of inflammatory bowel disease (IBD). Results: RNA-binding proteins post-transcriptionally regulate meprin α, and RNA stability decreases after induction of an inflammatory response. Conclusion: Inflammatory stimuli downregulate meprin α by inducing TTP expression and binding to the transcript. Significance: Determining how inflammation alters meprin α regulation is crucial to understanding its role in IBD.",
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Post-transcriptional regulation of meprin α by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP). / Roff, Alanna N.; Panganiban, Ronaldo P.; Bond, Judith S.; Ishmael, Faoud T.

In: Journal of Biological Chemistry, Vol. 288, No. 7, 15.02.2013, p. 4733-4743.

Research output: Contribution to journalArticle

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AU - Ishmael, Faoud T.

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