Post-transcriptional regulation of meprin α by the RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP)

Alanna N. Roff, Ronaldo P. Panganiban, Judith S. Bond, Faoud T. Ishmael

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Abstract

Background: Meprin α is a metalloproteinase implicated in the pathogenesis of inflammatory bowel disease (IBD). Results: RNA-binding proteins post-transcriptionally regulate meprin α, and RNA stability decreases after induction of an inflammatory response. Conclusion: Inflammatory stimuli downregulate meprin α by inducing TTP expression and binding to the transcript. Significance: Determining how inflammation alters meprin α regulation is crucial to understanding its role in IBD.

Original languageEnglish (US)
Pages (from-to)4733-4743
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number7
DOIs
StatePublished - Feb 15 2013

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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