Posterior reversible encephalopathy syndrome in pediatric patients: pathophysiology, diagnosis, and management

Michael G.Z. Ghali, Justin Davanzo, Madeline Leo, Elias Rizk

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Posterior reversible encephalopathy syndrome (PRES) is well-described in adults, but has been reported with relative rarity in children, usually occurring in the context of chemotherapy for acute leukemia. Pathogenesis involves perturbed cerebral autoregulation leading to vasogenic edema predominantly affecting the parieto-occipital white matter, though involvement of the frontal and temporal lobes, as well as posterior fossa, is also described. We review the literature on the pathophysiology, diagnosis, and management of PRES in pediatric patients.

Original languageEnglish (US)
Pages (from-to)2365-2372
Number of pages8
JournalLeukemia and Lymphoma
Volume60
Issue number10
DOIs
StatePublished - Aug 24 2019

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Cancer Research

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