Posttranscription initiation control of gene expression mediated by bacterial RNA-binding proteins

Paul Lee Babitzke, Ying Jung Lai, Andrew J. Renda, Tony Romeo

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

RNA-binding proteins play vital roles in regulating gene expression and cellular physiology in all organisms. Bacterial RNA-binding proteins can regulate transcription termination via attenuation or antitermination mechanisms, while others can repress or activate translation initiation by affecting ribosome binding. The RNA targets for these proteins include short repeated sequences, longer single-stranded sequences, RNA secondary or tertiary structure, and a combination of these features. The activity of these proteins can be influenced by binding of metabolites, small RNAs, or other proteins, as well as by phosphorylation events. Some of these proteins regulate specific genes, while others function as global regulators. As the regulatory mechanisms, components, targets, and signaling circuitry surrounding RNA-binding proteins have become better understood, in part through rapid advances provided by systems approaches, a sense of the true nature of biological complexity is becoming apparent, which we attempt to capture for the reader of this review.

Original languageEnglish (US)
Pages (from-to)43-67
Number of pages25
JournalAnnual Review of Microbiology
Volume73
DOIs
StatePublished - Jan 1 2019

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Bacterial RNA
RNA-Binding Proteins
Bacterial Proteins
Gene Expression
Proteins
RNA
Ribosomes
Phosphorylation
Genes

All Science Journal Classification (ASJC) codes

  • Microbiology

Cite this

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abstract = "RNA-binding proteins play vital roles in regulating gene expression and cellular physiology in all organisms. Bacterial RNA-binding proteins can regulate transcription termination via attenuation or antitermination mechanisms, while others can repress or activate translation initiation by affecting ribosome binding. The RNA targets for these proteins include short repeated sequences, longer single-stranded sequences, RNA secondary or tertiary structure, and a combination of these features. The activity of these proteins can be influenced by binding of metabolites, small RNAs, or other proteins, as well as by phosphorylation events. Some of these proteins regulate specific genes, while others function as global regulators. As the regulatory mechanisms, components, targets, and signaling circuitry surrounding RNA-binding proteins have become better understood, in part through rapid advances provided by systems approaches, a sense of the true nature of biological complexity is becoming apparent, which we attempt to capture for the reader of this review.",
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Posttranscription initiation control of gene expression mediated by bacterial RNA-binding proteins. / Babitzke, Paul Lee; Lai, Ying Jung; Renda, Andrew J.; Romeo, Tony.

In: Annual Review of Microbiology, Vol. 73, 01.01.2019, p. 43-67.

Research output: Contribution to journalReview article

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