Potassium changes associated with blood transfusion in pediatric patients

Jordan Olson, Mala Talekar, Mansi Sachdev, William Castellani, Nestor De La Cruz, Jerry Davis, Jason Liao, Melissa George

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Storing packed red blood cells (pRBCs) increases the potassium concentration. This effect is characterized in citrate phosphate dextrose/citrate phosphate dextrose adenine units but not published for Adsol (AS-5) units. The change in whole-blood potassium concentration in pediatric patients during routine transfusion is also poorly characterized. In this study, pediatric patients undergoing transfusion had pre- and posttransfusion whole-blood potassium measurements. The pRBC unit transfused and the unit's segment were sampled, with potassium concentration measured. In addition, potassium concentration in AS-5 units was measured over 42 days of storage. Unit extracellular potassium increased in AS-5 units after day 7 at 0.83 mmol/L/d. The mean change in patient potassium concentration was 0.08 mmol/L (range, -0.5 to 0.5 mmol/L). No correlation with unit age or unit potassium concentration was identified with change in patient whole-blood potassium concentration. The lack of clinical effect on patient potassium does not support the use of "fresh" pRBC units with routine pediatric transfusion.

Original languageEnglish (US)
Pages (from-to)800-805
Number of pages6
JournalAmerican journal of clinical pathology
Volume139
Issue number6
DOIs
StatePublished - Jun 2013

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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