Potassium changes associated with blood transfusion in pediatric patients

Jordan Olson, Mala Talekar, Mansi Sachdev, William Castellani, Nestor De La Cruz, Jerry Davis, Jason Liao, Melissa George

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Storing packed red blood cells (pRBCs) increases the potassium concentration. This effect is characterized in citrate phosphate dextrose/citrate phosphate dextrose adenine units but not published for Adsol (AS-5) units. The change in whole-blood potassium concentration in pediatric patients during routine transfusion is also poorly characterized. In this study, pediatric patients undergoing transfusion had pre- and posttransfusion whole-blood potassium measurements. The pRBC unit transfused and the unit's segment were sampled, with potassium concentration measured. In addition, potassium concentration in AS-5 units was measured over 42 days of storage. Unit extracellular potassium increased in AS-5 units after day 7 at 0.83 mmol/L/d. The mean change in patient potassium concentration was 0.08 mmol/L (range, -0.5 to 0.5 mmol/L). No correlation with unit age or unit potassium concentration was identified with change in patient whole-blood potassium concentration. The lack of clinical effect on patient potassium does not support the use of "fresh" pRBC units with routine pediatric transfusion.

Original languageEnglish (US)
Pages (from-to)800-805
Number of pages6
JournalAmerican journal of clinical pathology
Volume139
Issue number6
DOIs
StatePublished - Jun 1 2013

Fingerprint

Blood Transfusion
Potassium
Pediatrics
Erythrocytes
Adenine

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Olson, Jordan ; Talekar, Mala ; Sachdev, Mansi ; Castellani, William ; De La Cruz, Nestor ; Davis, Jerry ; Liao, Jason ; George, Melissa. / Potassium changes associated with blood transfusion in pediatric patients. In: American journal of clinical pathology. 2013 ; Vol. 139, No. 6. pp. 800-805.
@article{4377463121cd4c5b9b47fb9f41f967d0,
title = "Potassium changes associated with blood transfusion in pediatric patients",
abstract = "Storing packed red blood cells (pRBCs) increases the potassium concentration. This effect is characterized in citrate phosphate dextrose/citrate phosphate dextrose adenine units but not published for Adsol (AS-5) units. The change in whole-blood potassium concentration in pediatric patients during routine transfusion is also poorly characterized. In this study, pediatric patients undergoing transfusion had pre- and posttransfusion whole-blood potassium measurements. The pRBC unit transfused and the unit's segment were sampled, with potassium concentration measured. In addition, potassium concentration in AS-5 units was measured over 42 days of storage. Unit extracellular potassium increased in AS-5 units after day 7 at 0.83 mmol/L/d. The mean change in patient potassium concentration was 0.08 mmol/L (range, -0.5 to 0.5 mmol/L). No correlation with unit age or unit potassium concentration was identified with change in patient whole-blood potassium concentration. The lack of clinical effect on patient potassium does not support the use of {"}fresh{"} pRBC units with routine pediatric transfusion.",
author = "Jordan Olson and Mala Talekar and Mansi Sachdev and William Castellani and {De La Cruz}, Nestor and Jerry Davis and Jason Liao and Melissa George",
year = "2013",
month = "6",
day = "1",
doi = "10.1309/AJCP2MP8OIIXNKXF",
language = "English (US)",
volume = "139",
pages = "800--805",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "6",

}

Olson, J, Talekar, M, Sachdev, M, Castellani, W, De La Cruz, N, Davis, J, Liao, J & George, M 2013, 'Potassium changes associated with blood transfusion in pediatric patients', American journal of clinical pathology, vol. 139, no. 6, pp. 800-805. https://doi.org/10.1309/AJCP2MP8OIIXNKXF

Potassium changes associated with blood transfusion in pediatric patients. / Olson, Jordan; Talekar, Mala; Sachdev, Mansi; Castellani, William; De La Cruz, Nestor; Davis, Jerry; Liao, Jason; George, Melissa.

In: American journal of clinical pathology, Vol. 139, No. 6, 01.06.2013, p. 800-805.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Potassium changes associated with blood transfusion in pediatric patients

AU - Olson, Jordan

AU - Talekar, Mala

AU - Sachdev, Mansi

AU - Castellani, William

AU - De La Cruz, Nestor

AU - Davis, Jerry

AU - Liao, Jason

AU - George, Melissa

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Storing packed red blood cells (pRBCs) increases the potassium concentration. This effect is characterized in citrate phosphate dextrose/citrate phosphate dextrose adenine units but not published for Adsol (AS-5) units. The change in whole-blood potassium concentration in pediatric patients during routine transfusion is also poorly characterized. In this study, pediatric patients undergoing transfusion had pre- and posttransfusion whole-blood potassium measurements. The pRBC unit transfused and the unit's segment were sampled, with potassium concentration measured. In addition, potassium concentration in AS-5 units was measured over 42 days of storage. Unit extracellular potassium increased in AS-5 units after day 7 at 0.83 mmol/L/d. The mean change in patient potassium concentration was 0.08 mmol/L (range, -0.5 to 0.5 mmol/L). No correlation with unit age or unit potassium concentration was identified with change in patient whole-blood potassium concentration. The lack of clinical effect on patient potassium does not support the use of "fresh" pRBC units with routine pediatric transfusion.

AB - Storing packed red blood cells (pRBCs) increases the potassium concentration. This effect is characterized in citrate phosphate dextrose/citrate phosphate dextrose adenine units but not published for Adsol (AS-5) units. The change in whole-blood potassium concentration in pediatric patients during routine transfusion is also poorly characterized. In this study, pediatric patients undergoing transfusion had pre- and posttransfusion whole-blood potassium measurements. The pRBC unit transfused and the unit's segment were sampled, with potassium concentration measured. In addition, potassium concentration in AS-5 units was measured over 42 days of storage. Unit extracellular potassium increased in AS-5 units after day 7 at 0.83 mmol/L/d. The mean change in patient potassium concentration was 0.08 mmol/L (range, -0.5 to 0.5 mmol/L). No correlation with unit age or unit potassium concentration was identified with change in patient whole-blood potassium concentration. The lack of clinical effect on patient potassium does not support the use of "fresh" pRBC units with routine pediatric transfusion.

UR - http://www.scopus.com/inward/record.url?scp=84878418540&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878418540&partnerID=8YFLogxK

U2 - 10.1309/AJCP2MP8OIIXNKXF

DO - 10.1309/AJCP2MP8OIIXNKXF

M3 - Article

C2 - 23690124

AN - SCOPUS:84878418540

VL - 139

SP - 800

EP - 805

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 6

ER -

Olson J, Talekar M, Sachdev M, Castellani W, De La Cruz N, Davis J et al. Potassium changes associated with blood transfusion in pediatric patients. American journal of clinical pathology. 2013 Jun 1;139(6):800-805. https://doi.org/10.1309/AJCP2MP8OIIXNKXF