TY - JOUR
T1 - Potatoes for Targeting Colon Cancer Stem Cells
AU - Vanamala, Jairam K.P.
N1 - Funding Information:
Jairam K. P. Vanamala was the PI of the National Research Interest Integrated Grant 2009-55200-05197 from USDA-NIFA that supported the work. Thanks to Dr. Lavanya Reddivari for feedback and Linda J Brewer for valuable edits.
PY - 2019/4/15
Y1 - 2019/4/15
N2 - Colon cancer kills over 600,000 people annually worldwide. Unfortunately, current colon cancer prevention strategies like non-steroidal anti-inflammatory drugs (e.g., aspirin) can lead to serious adverse side effects such as intestinal bleeding. However, fruit and vegetable consumption has been associated with up to a 40% decrease in colon cancer risk. The benefits of a diet high in fruits and vegetables could be partly attributed to the bioactive components such as the fiber, resistant starch and polyphenolics present in them. Given that cancer incidence is expected to rise by about 70% over the next two decades, there is a critical need to develop staple foods that fight colon cancer. We recently reported that colored flesh potatoes that contain both resistant starch and polyphenols can target cancer stem cells. Thus, there is an opportunity to develop a staple food crop approach to targeting the growing epidemic of cancer globally.
AB - Colon cancer kills over 600,000 people annually worldwide. Unfortunately, current colon cancer prevention strategies like non-steroidal anti-inflammatory drugs (e.g., aspirin) can lead to serious adverse side effects such as intestinal bleeding. However, fruit and vegetable consumption has been associated with up to a 40% decrease in colon cancer risk. The benefits of a diet high in fruits and vegetables could be partly attributed to the bioactive components such as the fiber, resistant starch and polyphenolics present in them. Given that cancer incidence is expected to rise by about 70% over the next two decades, there is a critical need to develop staple foods that fight colon cancer. We recently reported that colored flesh potatoes that contain both resistant starch and polyphenols can target cancer stem cells. Thus, there is an opportunity to develop a staple food crop approach to targeting the growing epidemic of cancer globally.
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U2 - 10.1007/s12230-018-09700-9
DO - 10.1007/s12230-018-09700-9
M3 - Review article
AN - SCOPUS:85059698428
VL - 96
SP - 177
EP - 182
JO - American Journal of Potato Research
JF - American Journal of Potato Research
SN - 0003-0589
IS - 2
ER -