Potent inhibitors of the MAP kinase p38

James R. Henry, Kenneth C. Rupert, John H. Dodd, Ignatius J. Turchi, Scott A. Wadsworth, Druie E. Cavender, Peter H. Schafer, John J. Siekierka

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-α and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

Original languageEnglish (US)
Pages (from-to)3335-3340
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number23
DOIs
StatePublished - Dec 1 1998

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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