Potential for alcohol and prescription drug interactions in older people

Kristine E. Pringle, Frank Martin Ahern, Debra Ann Heller, Carol H. Gold, Theresa V. Brown

Research output: Contribution to journalReview article

79 Citations (Scopus)

Abstract

OBJECTIVES: To examine the patterns and prevalence of concomitant alcohol and alcohol-interactive (AI) drug use in older people. DESIGN: Cross-sectional analysis of survey and prescription claims data. SETTING: The Pennsylvania Pharmaceutical Assistance Contract for the Elderly (PA-PACE) program, a state-funded program providing prescription benefits to older people with low to moderate incomes. PARTICIPANTS: A total of 83,321 PA-PACE cardholders (age range 65-106) who were using any prescription medications at the time of survey completion. MEASUREMENTS: All AI drugs were identified using a database of medication warning labels obtained from First DataBank. Prescription drug claims were used to characterize AI drug exposure according to therapeutic class of prescription drug use. A mail survey of PA-PACE cardholders was used to examine alcohol use, as well as sociodemographic and health factors associated with concomitant use of alcohol and AI drugs. RESULTS: Seventy-seven percent of all prescription drug users were exposed to AI medications, with significant variation in exposure and concomitant alcohol use according to therapeutic class. Overall, 19% of AI drug users reported concomitant alcohol use, compared with 26% of non-AI drug users (P <.001). Multinomial logistic regression analyses showed that certain groups of older people, including younger older people, men, and those with higher educational levels, were at greater risk for concomitant exposure to alcohol and AI drugs. CONCLUSION: Many older people use alcohol in combination with AI prescription drugs. Clinicians should warn every patient who is prescribed an AI drug about alcohol-drug interactions, especially those at high risk for concomitant exposure.

Original languageEnglish (US)
Pages (from-to)1930-1936
Number of pages7
JournalJournal of the American Geriatrics Society
Volume53
Issue number11
DOIs
StatePublished - Nov 1 2005

Fingerprint

Prescription Drugs
Drug Interactions
Alcohols
Pharmaceutical Preparations
Contracts
Drug Users
Prescriptions
Cross-Sectional Studies
Databases
Postal Service

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology

Cite this

Pringle, Kristine E. ; Ahern, Frank Martin ; Heller, Debra Ann ; Gold, Carol H. ; Brown, Theresa V. / Potential for alcohol and prescription drug interactions in older people. In: Journal of the American Geriatrics Society. 2005 ; Vol. 53, No. 11. pp. 1930-1936.
@article{38e95ab6c6704af8a26ba32be517df60,
title = "Potential for alcohol and prescription drug interactions in older people",
abstract = "OBJECTIVES: To examine the patterns and prevalence of concomitant alcohol and alcohol-interactive (AI) drug use in older people. DESIGN: Cross-sectional analysis of survey and prescription claims data. SETTING: The Pennsylvania Pharmaceutical Assistance Contract for the Elderly (PA-PACE) program, a state-funded program providing prescription benefits to older people with low to moderate incomes. PARTICIPANTS: A total of 83,321 PA-PACE cardholders (age range 65-106) who were using any prescription medications at the time of survey completion. MEASUREMENTS: All AI drugs were identified using a database of medication warning labels obtained from First DataBank. Prescription drug claims were used to characterize AI drug exposure according to therapeutic class of prescription drug use. A mail survey of PA-PACE cardholders was used to examine alcohol use, as well as sociodemographic and health factors associated with concomitant use of alcohol and AI drugs. RESULTS: Seventy-seven percent of all prescription drug users were exposed to AI medications, with significant variation in exposure and concomitant alcohol use according to therapeutic class. Overall, 19{\%} of AI drug users reported concomitant alcohol use, compared with 26{\%} of non-AI drug users (P <.001). Multinomial logistic regression analyses showed that certain groups of older people, including younger older people, men, and those with higher educational levels, were at greater risk for concomitant exposure to alcohol and AI drugs. CONCLUSION: Many older people use alcohol in combination with AI prescription drugs. Clinicians should warn every patient who is prescribed an AI drug about alcohol-drug interactions, especially those at high risk for concomitant exposure.",
author = "Pringle, {Kristine E.} and Ahern, {Frank Martin} and Heller, {Debra Ann} and Gold, {Carol H.} and Brown, {Theresa V.}",
year = "2005",
month = "11",
day = "1",
doi = "10.1111/j.1532-5415.2005.00474.x",
language = "English (US)",
volume = "53",
pages = "1930--1936",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "11",

}

Potential for alcohol and prescription drug interactions in older people. / Pringle, Kristine E.; Ahern, Frank Martin; Heller, Debra Ann; Gold, Carol H.; Brown, Theresa V.

In: Journal of the American Geriatrics Society, Vol. 53, No. 11, 01.11.2005, p. 1930-1936.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Potential for alcohol and prescription drug interactions in older people

AU - Pringle, Kristine E.

AU - Ahern, Frank Martin

AU - Heller, Debra Ann

AU - Gold, Carol H.

AU - Brown, Theresa V.

PY - 2005/11/1

Y1 - 2005/11/1

N2 - OBJECTIVES: To examine the patterns and prevalence of concomitant alcohol and alcohol-interactive (AI) drug use in older people. DESIGN: Cross-sectional analysis of survey and prescription claims data. SETTING: The Pennsylvania Pharmaceutical Assistance Contract for the Elderly (PA-PACE) program, a state-funded program providing prescription benefits to older people with low to moderate incomes. PARTICIPANTS: A total of 83,321 PA-PACE cardholders (age range 65-106) who were using any prescription medications at the time of survey completion. MEASUREMENTS: All AI drugs were identified using a database of medication warning labels obtained from First DataBank. Prescription drug claims were used to characterize AI drug exposure according to therapeutic class of prescription drug use. A mail survey of PA-PACE cardholders was used to examine alcohol use, as well as sociodemographic and health factors associated with concomitant use of alcohol and AI drugs. RESULTS: Seventy-seven percent of all prescription drug users were exposed to AI medications, with significant variation in exposure and concomitant alcohol use according to therapeutic class. Overall, 19% of AI drug users reported concomitant alcohol use, compared with 26% of non-AI drug users (P <.001). Multinomial logistic regression analyses showed that certain groups of older people, including younger older people, men, and those with higher educational levels, were at greater risk for concomitant exposure to alcohol and AI drugs. CONCLUSION: Many older people use alcohol in combination with AI prescription drugs. Clinicians should warn every patient who is prescribed an AI drug about alcohol-drug interactions, especially those at high risk for concomitant exposure.

AB - OBJECTIVES: To examine the patterns and prevalence of concomitant alcohol and alcohol-interactive (AI) drug use in older people. DESIGN: Cross-sectional analysis of survey and prescription claims data. SETTING: The Pennsylvania Pharmaceutical Assistance Contract for the Elderly (PA-PACE) program, a state-funded program providing prescription benefits to older people with low to moderate incomes. PARTICIPANTS: A total of 83,321 PA-PACE cardholders (age range 65-106) who were using any prescription medications at the time of survey completion. MEASUREMENTS: All AI drugs were identified using a database of medication warning labels obtained from First DataBank. Prescription drug claims were used to characterize AI drug exposure according to therapeutic class of prescription drug use. A mail survey of PA-PACE cardholders was used to examine alcohol use, as well as sociodemographic and health factors associated with concomitant use of alcohol and AI drugs. RESULTS: Seventy-seven percent of all prescription drug users were exposed to AI medications, with significant variation in exposure and concomitant alcohol use according to therapeutic class. Overall, 19% of AI drug users reported concomitant alcohol use, compared with 26% of non-AI drug users (P <.001). Multinomial logistic regression analyses showed that certain groups of older people, including younger older people, men, and those with higher educational levels, were at greater risk for concomitant exposure to alcohol and AI drugs. CONCLUSION: Many older people use alcohol in combination with AI prescription drugs. Clinicians should warn every patient who is prescribed an AI drug about alcohol-drug interactions, especially those at high risk for concomitant exposure.

UR - http://www.scopus.com/inward/record.url?scp=29244489495&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29244489495&partnerID=8YFLogxK

U2 - 10.1111/j.1532-5415.2005.00474.x

DO - 10.1111/j.1532-5415.2005.00474.x

M3 - Review article

C2 - 16274374

AN - SCOPUS:29244489495

VL - 53

SP - 1930

EP - 1936

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 11

ER -