Potential influence of total parenteral nutrition on body composition at discharge in preterm infants

Jeffrey M. Meyers, Coleen P. Greecher, Michele L. Shaffer, Jeffrey S. Shenberger

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective: This study was undertaken to assess the potential influence of total parenteral nutrition (TPN) on body composition (BC) in preterm infants. Study design: This prospective, observational study of infants born <35 weeks measured BC at discharge using air displacement plethysmography. The % body fat (BF) at discharge was correlated with variables gestational age (GA), severity of illness, days on oxygen, time to regain birth weight and duration of TPN. Result: The 61 patients enrolled had a %BF at discharge of 13.9%. GA and TPN days correlated with %BF for the entire group. Multiple regression analysis identified that the time to regain birth weight added to the effect of GA, but not TPN. Isolating the influence of TPN in a subgroup of similarly aged infants (30-35 weeks) did not reveal a difference in body composition at the time of discharge between infants who did or did not receive TPN. Conclusion: These findings fail to demonstrate a clear influence of TPN on the increased accrual of BF in premature infants and implicate gestational modification in nutrient/caloric utilization as a principle regulator of body composition in premature newborns.

Original languageEnglish (US)
Pages (from-to)1548-1553
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume26
Issue number15
DOIs
StatePublished - Oct 2013

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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