Recent studies in neonatal animals have shown that hypoxic-ischemic brain damage can be reduced by interventions initiated after the hypoxic-ischemic insult. In this article, the authors focus on potentially new modalities of therapy capable of preventing - or at least reducing - brain damage arising from perinatal cerebral hypoxia-ischemia. Management strategies include oxygen-free radical inhibitors and scavengers, excitatory amino acid antagonists, and calcium channel blocker. Additional information is provided regarding the critical role of glucose in perinatal cerebral hypoxia-ischemia and also the protective effect of hypothermia on preventing brain damage.
|Original language||English (US)|
|Number of pages||22|
|Journal||Clinics in Perinatology|
|State||Published - 1993|
All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health