The strain difference, peroxisome proliferator specificity and role of PPARα in peroxisome proliferator-induced transcriptional repression of nonperoxisomal transthyretin and α(2u)-globulin genes were examined. The genes were repressed by four peroxisome proliferators in all seven mouse strains tested. The extent of repression was strongly dependent on both the mouse strains and type of proliferator, although the mRNA levels of PPARα and its partner in heterodimerization, RXRα were not different. The role of PPARα in repression was confirmed by the finding that PPARα-null mice were not responsive to transcriptional repression. These results indicate that PPARα plays an obligatory role in transcription of various genes, some of which are not related to lipid metabolism.
|Original language||English (US)|
|Number of pages||4|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jan 3 1997|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology