PPARα mediates peroxisome proliferator-induced transcriptional repression of nonperoxisomal gene expression in mouse

Kiyoto Motojima, Jeffrey Maurice Peters, Frank J. Gonzalez

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The strain difference, peroxisome proliferator specificity and role of PPARα in peroxisome proliferator-induced transcriptional repression of nonperoxisomal transthyretin and α(2u)-globulin genes were examined. The genes were repressed by four peroxisome proliferators in all seven mouse strains tested. The extent of repression was strongly dependent on both the mouse strains and type of proliferator, although the mRNA levels of PPARα and its partner in heterodimerization, RXRα were not different. The role of PPARα in repression was confirmed by the finding that PPARα-null mice were not responsive to transcriptional repression. These results indicate that PPARα plays an obligatory role in transcription of various genes, some of which are not related to lipid metabolism.

Original languageEnglish (US)
Pages (from-to)155-158
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume230
Issue number1
DOIs
StatePublished - Jan 3 1997

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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