PPARβ/δ selectively induces differentiation and inhibits cell proliferation

D. J. Kim, M. T. Bility, A. N. Billin, T. M. Willson, F. J. Gonzalez, J. M. Peters

Research output: Contribution to journalArticle

116 Scopus citations

Abstract

Peroxisome proliferator-activated receptor (PPAR) β-null mice exhibit exacerbated epithelial cell proliferation and enhanced sensitivity to skin carcinogenesis, suggesting that ligand activation of PPARβ will inhibit keratinocyte proliferation. By using of a highly specific ligand (GW0742) and the PPARβ-null mouse model, activation of PPARβ was found to selectively induce keratinocyte terminal differentiation and inhibit keratinocyte proliferation. Additionally, GW0742 was found to be anti-inflammatory due to inhibition of myeloperoxidase activity, independent of PPARβ. These data suggest that ligand activation of PPARβ could be a novel approach to selectively induce differentiation and inhibit cell proliferation, thus representing a new molecular target for the treatment of skin disorders resulting from altered cell proliferation such as psoriasis and cancer.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalCell Death and Differentiation
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2006

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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