Abstract

Metabolomic analysis will provide the next large set of clues to further our understanding of human health and disease. A recent study has elucidated the significant differences in the metabolomes of adipocytes, serum and an adipocyte cell line after activation of two nuclear receptors, peroxisome proliferator activated receptor β/∂ (PPARβ/∂) and PPARγ. These findings hold great promise for explaining fundamental differences in the mechanisms of PPAR agonists and for identifying targets for the treatment of diabetes.

Original languageEnglish (US)
Article number54
JournalGenome Medicine
Volume3
Issue number8
DOIs
StatePublished - Aug 23 2011

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Peroxisome Proliferator-Activated Receptors
Metabolomics
Insulin Resistance
Adipocytes
Metabolome
Cytoplasmic and Nuclear Receptors
Cell Line
Health
Serum

All Science Journal Classification (ASJC) codes

  • Genetics(clinical)
  • Genetics
  • Molecular Biology
  • Molecular Medicine

Cite this

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abstract = "Metabolomic analysis will provide the next large set of clues to further our understanding of human health and disease. A recent study has elucidated the significant differences in the metabolomes of adipocytes, serum and an adipocyte cell line after activation of two nuclear receptors, peroxisome proliferator activated receptor β/∂ (PPARβ/∂) and PPARγ. These findings hold great promise for explaining fundamental differences in the mechanisms of PPAR agonists and for identifying targets for the treatment of diabetes.",
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