Pre-pregnancy BMI, gestational weight gain, and the risk of hypertensive disorders of pregnancy: A cohort study in Wuhan, China

Aifen Zhou, Chao Xiong, Ronghua Hu, Yiming Zhang, Bryan A. Bassig, Elizabeth Triche, Shaoping Yang, Lin Qiu, Yaqi Zhang, Cong Yao, Shunqing Xu, Youjie Wang, Wei Xia, Zhengmin Qian, Tongzhang Zheng, Bin Zhang

Research output: Contribution to journalArticle

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Abstract

Background: Hypertensive disorders of pregnancy (HDP) are major causes of maternal death worldwide and the risk factors are not fully understood. Few studies have investigated the risk factors for HDP among Chinese women. A cohort study involving 84,656 women was conducted to investigate pre-pregnancy BMI, total gestational weight gain (GWG), and GWG during early pregnancy as risk factors for HDP among Chinese women. Methods: The study was conducted between 2011-2013 in Wuhan, China, utilizing data from the Maternal and Children Healthcare Information Tracking System of Wuhan. A total of 84,656 women with a live singleton pregnancy were included. Multiple unconditional logistic regression was conducted to evaluate associations between putative risk factors and HDP. Results: Women who were overweight or obese before pregnancy had an elevated risk of developing HDP (overweight: OR = 2.66, 95% CI = 2.32-3.05; obese: OR = 5.53, 95% CI = 4.28- 7.13) compared to their normal weight counterparts. Women with total GWG above the Institute of Medicine (IOM) recommendation had an adjusted OR of 1.72 (95% CI = 1.54-1.93) for HDP compared to women who had GWG within the IOM recommendation. Women with gestational BMI gain >10 kg/m2 during pregnancy had an adjusted OR of 3.35 (95% CI = 2.89-3.89) for HDP, compared to women with a gestational BMI gain <5 kg/m2. The increased risk of HDP was also observed among women with higher early pregnancy (up to 18 weeks of pregnancy) GWG (>600g/wk: adjusted OR = 1.48, 95% CI = 1.19-1.84). Conclusion: The results from this study show that maternal pre-pregnancy BMI, early GWG, and total GWG are positively associated with the risk of HDP. Weight control efforts before and during pregnancy may help to reduce the risk of HDP.

Original languageEnglish (US)
Article numbere0136291
JournalPloS one
Volume10
Issue number8
DOIs
StatePublished - Aug 25 2015

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cohort studies
hypertension
Weight Gain
China
Cohort Studies
weight gain
pregnancy
Pregnancy
Medicine
Weight control
risk factors
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Logistics
medicine
Mothers
Weights and Measures
Maternal Death
information systems
weight control
hypertensive factor

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Zhou, Aifen ; Xiong, Chao ; Hu, Ronghua ; Zhang, Yiming ; Bassig, Bryan A. ; Triche, Elizabeth ; Yang, Shaoping ; Qiu, Lin ; Zhang, Yaqi ; Yao, Cong ; Xu, Shunqing ; Wang, Youjie ; Xia, Wei ; Qian, Zhengmin ; Zheng, Tongzhang ; Zhang, Bin. / Pre-pregnancy BMI, gestational weight gain, and the risk of hypertensive disorders of pregnancy : A cohort study in Wuhan, China. In: PloS one. 2015 ; Vol. 10, No. 8.
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title = "Pre-pregnancy BMI, gestational weight gain, and the risk of hypertensive disorders of pregnancy: A cohort study in Wuhan, China",
abstract = "Background: Hypertensive disorders of pregnancy (HDP) are major causes of maternal death worldwide and the risk factors are not fully understood. Few studies have investigated the risk factors for HDP among Chinese women. A cohort study involving 84,656 women was conducted to investigate pre-pregnancy BMI, total gestational weight gain (GWG), and GWG during early pregnancy as risk factors for HDP among Chinese women. Methods: The study was conducted between 2011-2013 in Wuhan, China, utilizing data from the Maternal and Children Healthcare Information Tracking System of Wuhan. A total of 84,656 women with a live singleton pregnancy were included. Multiple unconditional logistic regression was conducted to evaluate associations between putative risk factors and HDP. Results: Women who were overweight or obese before pregnancy had an elevated risk of developing HDP (overweight: OR = 2.66, 95{\%} CI = 2.32-3.05; obese: OR = 5.53, 95{\%} CI = 4.28- 7.13) compared to their normal weight counterparts. Women with total GWG above the Institute of Medicine (IOM) recommendation had an adjusted OR of 1.72 (95{\%} CI = 1.54-1.93) for HDP compared to women who had GWG within the IOM recommendation. Women with gestational BMI gain >10 kg/m2 during pregnancy had an adjusted OR of 3.35 (95{\%} CI = 2.89-3.89) for HDP, compared to women with a gestational BMI gain <5 kg/m2. The increased risk of HDP was also observed among women with higher early pregnancy (up to 18 weeks of pregnancy) GWG (>600g/wk: adjusted OR = 1.48, 95{\%} CI = 1.19-1.84). Conclusion: The results from this study show that maternal pre-pregnancy BMI, early GWG, and total GWG are positively associated with the risk of HDP. Weight control efforts before and during pregnancy may help to reduce the risk of HDP.",
author = "Aifen Zhou and Chao Xiong and Ronghua Hu and Yiming Zhang and Bassig, {Bryan A.} and Elizabeth Triche and Shaoping Yang and Lin Qiu and Yaqi Zhang and Cong Yao and Shunqing Xu and Youjie Wang and Wei Xia and Zhengmin Qian and Tongzhang Zheng and Bin Zhang",
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Zhou, A, Xiong, C, Hu, R, Zhang, Y, Bassig, BA, Triche, E, Yang, S, Qiu, L, Zhang, Y, Yao, C, Xu, S, Wang, Y, Xia, W, Qian, Z, Zheng, T & Zhang, B 2015, 'Pre-pregnancy BMI, gestational weight gain, and the risk of hypertensive disorders of pregnancy: A cohort study in Wuhan, China', PloS one, vol. 10, no. 8, e0136291. https://doi.org/10.1371/journal.pone.0136291

Pre-pregnancy BMI, gestational weight gain, and the risk of hypertensive disorders of pregnancy : A cohort study in Wuhan, China. / Zhou, Aifen; Xiong, Chao; Hu, Ronghua; Zhang, Yiming; Bassig, Bryan A.; Triche, Elizabeth; Yang, Shaoping; Qiu, Lin; Zhang, Yaqi; Yao, Cong; Xu, Shunqing; Wang, Youjie; Xia, Wei; Qian, Zhengmin; Zheng, Tongzhang; Zhang, Bin.

In: PloS one, Vol. 10, No. 8, e0136291, 25.08.2015.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pre-pregnancy BMI, gestational weight gain, and the risk of hypertensive disorders of pregnancy

T2 - A cohort study in Wuhan, China

AU - Zhou, Aifen

AU - Xiong, Chao

AU - Hu, Ronghua

AU - Zhang, Yiming

AU - Bassig, Bryan A.

AU - Triche, Elizabeth

AU - Yang, Shaoping

AU - Qiu, Lin

AU - Zhang, Yaqi

AU - Yao, Cong

AU - Xu, Shunqing

AU - Wang, Youjie

AU - Xia, Wei

AU - Qian, Zhengmin

AU - Zheng, Tongzhang

AU - Zhang, Bin

PY - 2015/8/25

Y1 - 2015/8/25

N2 - Background: Hypertensive disorders of pregnancy (HDP) are major causes of maternal death worldwide and the risk factors are not fully understood. Few studies have investigated the risk factors for HDP among Chinese women. A cohort study involving 84,656 women was conducted to investigate pre-pregnancy BMI, total gestational weight gain (GWG), and GWG during early pregnancy as risk factors for HDP among Chinese women. Methods: The study was conducted between 2011-2013 in Wuhan, China, utilizing data from the Maternal and Children Healthcare Information Tracking System of Wuhan. A total of 84,656 women with a live singleton pregnancy were included. Multiple unconditional logistic regression was conducted to evaluate associations between putative risk factors and HDP. Results: Women who were overweight or obese before pregnancy had an elevated risk of developing HDP (overweight: OR = 2.66, 95% CI = 2.32-3.05; obese: OR = 5.53, 95% CI = 4.28- 7.13) compared to their normal weight counterparts. Women with total GWG above the Institute of Medicine (IOM) recommendation had an adjusted OR of 1.72 (95% CI = 1.54-1.93) for HDP compared to women who had GWG within the IOM recommendation. Women with gestational BMI gain >10 kg/m2 during pregnancy had an adjusted OR of 3.35 (95% CI = 2.89-3.89) for HDP, compared to women with a gestational BMI gain <5 kg/m2. The increased risk of HDP was also observed among women with higher early pregnancy (up to 18 weeks of pregnancy) GWG (>600g/wk: adjusted OR = 1.48, 95% CI = 1.19-1.84). Conclusion: The results from this study show that maternal pre-pregnancy BMI, early GWG, and total GWG are positively associated with the risk of HDP. Weight control efforts before and during pregnancy may help to reduce the risk of HDP.

AB - Background: Hypertensive disorders of pregnancy (HDP) are major causes of maternal death worldwide and the risk factors are not fully understood. Few studies have investigated the risk factors for HDP among Chinese women. A cohort study involving 84,656 women was conducted to investigate pre-pregnancy BMI, total gestational weight gain (GWG), and GWG during early pregnancy as risk factors for HDP among Chinese women. Methods: The study was conducted between 2011-2013 in Wuhan, China, utilizing data from the Maternal and Children Healthcare Information Tracking System of Wuhan. A total of 84,656 women with a live singleton pregnancy were included. Multiple unconditional logistic regression was conducted to evaluate associations between putative risk factors and HDP. Results: Women who were overweight or obese before pregnancy had an elevated risk of developing HDP (overweight: OR = 2.66, 95% CI = 2.32-3.05; obese: OR = 5.53, 95% CI = 4.28- 7.13) compared to their normal weight counterparts. Women with total GWG above the Institute of Medicine (IOM) recommendation had an adjusted OR of 1.72 (95% CI = 1.54-1.93) for HDP compared to women who had GWG within the IOM recommendation. Women with gestational BMI gain >10 kg/m2 during pregnancy had an adjusted OR of 3.35 (95% CI = 2.89-3.89) for HDP, compared to women with a gestational BMI gain <5 kg/m2. The increased risk of HDP was also observed among women with higher early pregnancy (up to 18 weeks of pregnancy) GWG (>600g/wk: adjusted OR = 1.48, 95% CI = 1.19-1.84). Conclusion: The results from this study show that maternal pre-pregnancy BMI, early GWG, and total GWG are positively associated with the risk of HDP. Weight control efforts before and during pregnancy may help to reduce the risk of HDP.

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