Pre-to-post diagnosis weight trajectories in colorectal cancer patients with non-metastatic disease

Moniek van Zutphen, Anouk Geelen, Hendriek C. Boshuizen, Renate Winkels, Anne J.M.R. Geijsen, Evertine Wesselink, Merel Snellen, Dieuwertje E. Kok, Johannes H.W. de Wilt, Paul C. van de Meeberg, Ewout A. Kouwenhoven, Henk K. van Halteren, Ernst J. Spillenaar Bilgen, Ellen Kampman, Fränzel J.B. van Duijnhoven

Research output: Contribution to journalArticle

Abstract

Purpose: Previous studies have shown that > 50% of colorectal cancer (CRC) patients treated with adjuvant chemotherapy gain weight after diagnosis. This may affect long-term health. Therefore, prevention of weight gain has been incorporated in oncological guidelines for CRC with a focus on patients that undergo adjuvant chemotherapy treatment. It is, however, unknown how changes in weight after diagnosis relate to weight before diagnosis and whether weight changes from pre-to-post diagnosis are restricted to chemotherapy treatment. We therefore examined pre-to-post diagnosis weight trajectories and compared them between those treated with and without adjuvant chemotherapy. Methods: We included 1184 patients diagnosed with stages I–III CRC between 2010 and 2015 from an ongoing observational prospective study. At diagnosis, patients reported current weight and usual weight 2 years before diagnosis. In the 2 years following diagnosis, weight was self-reported repeatedly. We used linear mixed models to analyse weight trajectories. Results: Mean pre-to-post diagnosis weight change was −0.8 (95% CI −1.1, −0.4) kg. Post-diagnosis weight gain was + 3.5 (95% CI 2.7, 4.3) kg in patients who had lost ≥ 5% weight before diagnosis, while on average clinically relevant weight gain after diagnosis was absent in the groups without pre-diagnosis weight loss. Pre-to-post diagnosis weight change was similar in patients treated with (−0.1 kg (95%CI −0.8, 0.6)) and without adjuvant chemotherapy (−0.9 kg (95%CI −1.4, −0.5)). Conclusions: Overall, hardly any pre-to-post diagnosis weight change was observed among CRC patients, because post-diagnosis weight gain was mainly observed in patients who lost weight before diagnosis. This was observed independent of treatment with adjuvant chemotherapy.

Original languageEnglish (US)
Pages (from-to)1541-1549
Number of pages9
JournalSupportive Care in Cancer
Volume27
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

Colorectal Neoplasms
Weights and Measures
Adjuvant Chemotherapy
Weight Gain
Observational Studies
Weight Loss
Linear Models
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

van Zutphen, M., Geelen, A., Boshuizen, H. C., Winkels, R., Geijsen, A. J. M. R., Wesselink, E., ... van Duijnhoven, F. J. B. (2019). Pre-to-post diagnosis weight trajectories in colorectal cancer patients with non-metastatic disease. Supportive Care in Cancer, 27(4), 1541-1549. https://doi.org/10.1007/s00520-018-4560-z
van Zutphen, Moniek ; Geelen, Anouk ; Boshuizen, Hendriek C. ; Winkels, Renate ; Geijsen, Anne J.M.R. ; Wesselink, Evertine ; Snellen, Merel ; Kok, Dieuwertje E. ; de Wilt, Johannes H.W. ; van de Meeberg, Paul C. ; Kouwenhoven, Ewout A. ; van Halteren, Henk K. ; Spillenaar Bilgen, Ernst J. ; Kampman, Ellen ; van Duijnhoven, Fränzel J.B. / Pre-to-post diagnosis weight trajectories in colorectal cancer patients with non-metastatic disease. In: Supportive Care in Cancer. 2019 ; Vol. 27, No. 4. pp. 1541-1549.
@article{dc54202b630c42378c66d4059c3f41e9,
title = "Pre-to-post diagnosis weight trajectories in colorectal cancer patients with non-metastatic disease",
abstract = "Purpose: Previous studies have shown that > 50{\%} of colorectal cancer (CRC) patients treated with adjuvant chemotherapy gain weight after diagnosis. This may affect long-term health. Therefore, prevention of weight gain has been incorporated in oncological guidelines for CRC with a focus on patients that undergo adjuvant chemotherapy treatment. It is, however, unknown how changes in weight after diagnosis relate to weight before diagnosis and whether weight changes from pre-to-post diagnosis are restricted to chemotherapy treatment. We therefore examined pre-to-post diagnosis weight trajectories and compared them between those treated with and without adjuvant chemotherapy. Methods: We included 1184 patients diagnosed with stages I–III CRC between 2010 and 2015 from an ongoing observational prospective study. At diagnosis, patients reported current weight and usual weight 2 years before diagnosis. In the 2 years following diagnosis, weight was self-reported repeatedly. We used linear mixed models to analyse weight trajectories. Results: Mean pre-to-post diagnosis weight change was −0.8 (95{\%} CI −1.1, −0.4) kg. Post-diagnosis weight gain was + 3.5 (95{\%} CI 2.7, 4.3) kg in patients who had lost ≥ 5{\%} weight before diagnosis, while on average clinically relevant weight gain after diagnosis was absent in the groups without pre-diagnosis weight loss. Pre-to-post diagnosis weight change was similar in patients treated with (−0.1 kg (95{\%}CI −0.8, 0.6)) and without adjuvant chemotherapy (−0.9 kg (95{\%}CI −1.4, −0.5)). Conclusions: Overall, hardly any pre-to-post diagnosis weight change was observed among CRC patients, because post-diagnosis weight gain was mainly observed in patients who lost weight before diagnosis. This was observed independent of treatment with adjuvant chemotherapy.",
author = "{van Zutphen}, Moniek and Anouk Geelen and Boshuizen, {Hendriek C.} and Renate Winkels and Geijsen, {Anne J.M.R.} and Evertine Wesselink and Merel Snellen and Kok, {Dieuwertje E.} and {de Wilt}, {Johannes H.W.} and {van de Meeberg}, {Paul C.} and Kouwenhoven, {Ewout A.} and {van Halteren}, {Henk K.} and {Spillenaar Bilgen}, {Ernst J.} and Ellen Kampman and {van Duijnhoven}, {Fr{\"a}nzel J.B.}",
year = "2019",
month = "4",
day = "1",
doi = "10.1007/s00520-018-4560-z",
language = "English (US)",
volume = "27",
pages = "1541--1549",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer Verlag",
number = "4",

}

van Zutphen, M, Geelen, A, Boshuizen, HC, Winkels, R, Geijsen, AJMR, Wesselink, E, Snellen, M, Kok, DE, de Wilt, JHW, van de Meeberg, PC, Kouwenhoven, EA, van Halteren, HK, Spillenaar Bilgen, EJ, Kampman, E & van Duijnhoven, FJB 2019, 'Pre-to-post diagnosis weight trajectories in colorectal cancer patients with non-metastatic disease', Supportive Care in Cancer, vol. 27, no. 4, pp. 1541-1549. https://doi.org/10.1007/s00520-018-4560-z

Pre-to-post diagnosis weight trajectories in colorectal cancer patients with non-metastatic disease. / van Zutphen, Moniek; Geelen, Anouk; Boshuizen, Hendriek C.; Winkels, Renate; Geijsen, Anne J.M.R.; Wesselink, Evertine; Snellen, Merel; Kok, Dieuwertje E.; de Wilt, Johannes H.W.; van de Meeberg, Paul C.; Kouwenhoven, Ewout A.; van Halteren, Henk K.; Spillenaar Bilgen, Ernst J.; Kampman, Ellen; van Duijnhoven, Fränzel J.B.

In: Supportive Care in Cancer, Vol. 27, No. 4, 01.04.2019, p. 1541-1549.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Pre-to-post diagnosis weight trajectories in colorectal cancer patients with non-metastatic disease

AU - van Zutphen, Moniek

AU - Geelen, Anouk

AU - Boshuizen, Hendriek C.

AU - Winkels, Renate

AU - Geijsen, Anne J.M.R.

AU - Wesselink, Evertine

AU - Snellen, Merel

AU - Kok, Dieuwertje E.

AU - de Wilt, Johannes H.W.

AU - van de Meeberg, Paul C.

AU - Kouwenhoven, Ewout A.

AU - van Halteren, Henk K.

AU - Spillenaar Bilgen, Ernst J.

AU - Kampman, Ellen

AU - van Duijnhoven, Fränzel J.B.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Purpose: Previous studies have shown that > 50% of colorectal cancer (CRC) patients treated with adjuvant chemotherapy gain weight after diagnosis. This may affect long-term health. Therefore, prevention of weight gain has been incorporated in oncological guidelines for CRC with a focus on patients that undergo adjuvant chemotherapy treatment. It is, however, unknown how changes in weight after diagnosis relate to weight before diagnosis and whether weight changes from pre-to-post diagnosis are restricted to chemotherapy treatment. We therefore examined pre-to-post diagnosis weight trajectories and compared them between those treated with and without adjuvant chemotherapy. Methods: We included 1184 patients diagnosed with stages I–III CRC between 2010 and 2015 from an ongoing observational prospective study. At diagnosis, patients reported current weight and usual weight 2 years before diagnosis. In the 2 years following diagnosis, weight was self-reported repeatedly. We used linear mixed models to analyse weight trajectories. Results: Mean pre-to-post diagnosis weight change was −0.8 (95% CI −1.1, −0.4) kg. Post-diagnosis weight gain was + 3.5 (95% CI 2.7, 4.3) kg in patients who had lost ≥ 5% weight before diagnosis, while on average clinically relevant weight gain after diagnosis was absent in the groups without pre-diagnosis weight loss. Pre-to-post diagnosis weight change was similar in patients treated with (−0.1 kg (95%CI −0.8, 0.6)) and without adjuvant chemotherapy (−0.9 kg (95%CI −1.4, −0.5)). Conclusions: Overall, hardly any pre-to-post diagnosis weight change was observed among CRC patients, because post-diagnosis weight gain was mainly observed in patients who lost weight before diagnosis. This was observed independent of treatment with adjuvant chemotherapy.

AB - Purpose: Previous studies have shown that > 50% of colorectal cancer (CRC) patients treated with adjuvant chemotherapy gain weight after diagnosis. This may affect long-term health. Therefore, prevention of weight gain has been incorporated in oncological guidelines for CRC with a focus on patients that undergo adjuvant chemotherapy treatment. It is, however, unknown how changes in weight after diagnosis relate to weight before diagnosis and whether weight changes from pre-to-post diagnosis are restricted to chemotherapy treatment. We therefore examined pre-to-post diagnosis weight trajectories and compared them between those treated with and without adjuvant chemotherapy. Methods: We included 1184 patients diagnosed with stages I–III CRC between 2010 and 2015 from an ongoing observational prospective study. At diagnosis, patients reported current weight and usual weight 2 years before diagnosis. In the 2 years following diagnosis, weight was self-reported repeatedly. We used linear mixed models to analyse weight trajectories. Results: Mean pre-to-post diagnosis weight change was −0.8 (95% CI −1.1, −0.4) kg. Post-diagnosis weight gain was + 3.5 (95% CI 2.7, 4.3) kg in patients who had lost ≥ 5% weight before diagnosis, while on average clinically relevant weight gain after diagnosis was absent in the groups without pre-diagnosis weight loss. Pre-to-post diagnosis weight change was similar in patients treated with (−0.1 kg (95%CI −0.8, 0.6)) and without adjuvant chemotherapy (−0.9 kg (95%CI −1.4, −0.5)). Conclusions: Overall, hardly any pre-to-post diagnosis weight change was observed among CRC patients, because post-diagnosis weight gain was mainly observed in patients who lost weight before diagnosis. This was observed independent of treatment with adjuvant chemotherapy.

UR - http://www.scopus.com/inward/record.url?scp=85057322032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057322032&partnerID=8YFLogxK

U2 - 10.1007/s00520-018-4560-z

DO - 10.1007/s00520-018-4560-z

M3 - Article

VL - 27

SP - 1541

EP - 1549

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 4

ER -

van Zutphen M, Geelen A, Boshuizen HC, Winkels R, Geijsen AJMR, Wesselink E et al. Pre-to-post diagnosis weight trajectories in colorectal cancer patients with non-metastatic disease. Supportive Care in Cancer. 2019 Apr 1;27(4):1541-1549. https://doi.org/10.1007/s00520-018-4560-z