Abstract
A commonly pursued goal in studying synaptic plasticity is to determine whether synaptic inputs undergo presynaptic and/or postsynaptic alterations following a stimulus and how these alterations affect the firing properties of the innervated neuron. In this chapter we continue to discuss approaches that can be implemented to test presynaptic mechanisms of plasticity. In addition, we explain modifications that can occur in the postsynaptic cell affecting the intrinsic membrane excitability. The intrinsic membrane excitability contributes to the firing properties of a neuron, and is mediated by voltage-gated channels as well as synaptic inputs. In this chapter, we discuss the voltage-gated channels that regulate the intrinsic membrane excitability on the dendrite explaining how these channels contribute to EPSP summation at the soma and back-propagating action potentials. We conclude this chapter with approaches that can be used to measure the intrinsic membrane excitability.
| Original language | English (US) |
|---|---|
| Title of host publication | Neuromethods |
| Publisher | Humana Press Inc. |
| Pages | 175-186 |
| Number of pages | 12 |
| DOIs | |
| State | Published - Oct 1 2016 |
Publication series
| Name | Neuromethods |
|---|---|
| Volume | 112 |
| ISSN (Print) | 0893-2336 |
| ISSN (Electronic) | 1940-6045 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
- Psychiatry and Mental health
Cite this
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Pre vs. Post synaptic effect. / Graziane, Nicholas; Dong, Yan.
Neuromethods. Humana Press Inc., 2016. p. 175-186 (Neuromethods; Vol. 112).Research output: Chapter in Book/Report/Conference proceeding › Chapter
TY - CHAP
T1 - Pre vs. Post synaptic effect
AU - Graziane, Nicholas
AU - Dong, Yan
PY - 2016/10/1
Y1 - 2016/10/1
N2 - A commonly pursued goal in studying synaptic plasticity is to determine whether synaptic inputs undergo presynaptic and/or postsynaptic alterations following a stimulus and how these alterations affect the firing properties of the innervated neuron. In this chapter we continue to discuss approaches that can be implemented to test presynaptic mechanisms of plasticity. In addition, we explain modifications that can occur in the postsynaptic cell affecting the intrinsic membrane excitability. The intrinsic membrane excitability contributes to the firing properties of a neuron, and is mediated by voltage-gated channels as well as synaptic inputs. In this chapter, we discuss the voltage-gated channels that regulate the intrinsic membrane excitability on the dendrite explaining how these channels contribute to EPSP summation at the soma and back-propagating action potentials. We conclude this chapter with approaches that can be used to measure the intrinsic membrane excitability.
AB - A commonly pursued goal in studying synaptic plasticity is to determine whether synaptic inputs undergo presynaptic and/or postsynaptic alterations following a stimulus and how these alterations affect the firing properties of the innervated neuron. In this chapter we continue to discuss approaches that can be implemented to test presynaptic mechanisms of plasticity. In addition, we explain modifications that can occur in the postsynaptic cell affecting the intrinsic membrane excitability. The intrinsic membrane excitability contributes to the firing properties of a neuron, and is mediated by voltage-gated channels as well as synaptic inputs. In this chapter, we discuss the voltage-gated channels that regulate the intrinsic membrane excitability on the dendrite explaining how these channels contribute to EPSP summation at the soma and back-propagating action potentials. We conclude this chapter with approaches that can be used to measure the intrinsic membrane excitability.
UR - http://www.scopus.com/inward/record.url?scp=84950324954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84950324954&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-3274-0_15
DO - 10.1007/978-1-4939-3274-0_15
M3 - Chapter
AN - SCOPUS:84950324954
T3 - Neuromethods
SP - 175
EP - 186
BT - Neuromethods
PB - Humana Press Inc.
ER -