Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice

Yuan Tian, Robert G. Nichols, Pratiti Roy, Wei Gui, Philip B. Smith, Jingtao Zhang, Yangding Lin, Veronika Weaver, Jingwei Cai, Andrew David Patterson, Margherita Teresa-Anna Cantorna

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The mechanisms by which white button (WB) mushrooms (Agaricus bisporus) may influence health are unclear. WB feeding (1%) resulted in changes in the composition of microbiota in conventional (CV) mice to expand a population of Prevotella that produce propionate and succinate. Microbial propionate and succinate production induced expression of genes important for intestinal gluconeogenesis (IGN) via the gut-brain neural circuit. Reduced hepatic glucose production was a metabolic benefit of IGN that was found in WB fed CV mice. In the absence of microbiota or in mice with disruptions in the ability to sense microbiota there was no WB mediated effect. WB-fed lean mice had a small but significant improvement in glucose sensitivity. WB feeding resulted in shifts in the microbiota that induced IGN and improved glucose homeostasis.

Original languageEnglish (US)
Pages (from-to)223-232
Number of pages10
JournalJournal of Functional Foods
Volume45
DOIs
StatePublished - Jun 1 2018

Fingerprint

Agaricus
Prebiotics
Agaricus bisporus
Gluconeogenesis
gluconeogenesis
Agaricales
Succinic Acid
prebiotics
succinic acid
Inbred C57BL Mouse
mushrooms
Microbiota
Propionates
mice
propionates
Glucose
glucose
Prevotella
homeostasis
Homeostasis

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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title = "Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice",
abstract = "The mechanisms by which white button (WB) mushrooms (Agaricus bisporus) may influence health are unclear. WB feeding (1{\%}) resulted in changes in the composition of microbiota in conventional (CV) mice to expand a population of Prevotella that produce propionate and succinate. Microbial propionate and succinate production induced expression of genes important for intestinal gluconeogenesis (IGN) via the gut-brain neural circuit. Reduced hepatic glucose production was a metabolic benefit of IGN that was found in WB fed CV mice. In the absence of microbiota or in mice with disruptions in the ability to sense microbiota there was no WB mediated effect. WB-fed lean mice had a small but significant improvement in glucose sensitivity. WB feeding resulted in shifts in the microbiota that induced IGN and improved glucose homeostasis.",
author = "Yuan Tian and Nichols, {Robert G.} and Pratiti Roy and Wei Gui and Smith, {Philip B.} and Jingtao Zhang and Yangding Lin and Veronika Weaver and Jingwei Cai and Patterson, {Andrew David} and Cantorna, {Margherita Teresa-Anna}",
year = "2018",
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Prebiotic effects of white button mushroom (Agaricus bisporus) feeding on succinate and intestinal gluconeogenesis in C57BL/6 mice. / Tian, Yuan; Nichols, Robert G.; Roy, Pratiti; Gui, Wei; Smith, Philip B.; Zhang, Jingtao; Lin, Yangding; Weaver, Veronika; Cai, Jingwei; Patterson, Andrew David; Cantorna, Margherita Teresa-Anna.

In: Journal of Functional Foods, Vol. 45, 01.06.2018, p. 223-232.

Research output: Contribution to journalArticle

TY - JOUR

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AU - Tian, Yuan

AU - Nichols, Robert G.

AU - Roy, Pratiti

AU - Gui, Wei

AU - Smith, Philip B.

AU - Zhang, Jingtao

AU - Lin, Yangding

AU - Weaver, Veronika

AU - Cai, Jingwei

AU - Patterson, Andrew David

AU - Cantorna, Margherita Teresa-Anna

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